Inhibitory Effect of Triterpenoid Saponins from the Leaves of Ilex kudingcha on Aggregated LDL-Induced Lipid Deposition in Macrophages

Jiao Zheng, Li Tang, Xun De Xian, Si Xiang Zhou, Hai Ming Shi, Yong Jiang, Yue Qing Gu, George Liu, Peng Fei Tu

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

We have investigated the inhibitory effect of triterpenoid saponins from the leaves of Ilex kudingcha C. J. Tseng on aggregated low-density lipoprotein (LDL)-induced lipid deposition in macrophages. A cell-based screening modelwas initially applied on aggregated LDL (aggLDL)-induced lipid deposition on macrophages to test the inhibitory effects of the 12 triterpenoid saponins from this plant. Eight of these compounds inhibited the formation of foam cells and reduced intracellular total cholesterol and triglyceride contents. Structure-activity relationship analysis showed the essential role of the δ-lactone ring for the biological activity. The promoter action of the OH group at the C-12 position, the number of monosaccharides in the sugar chain and the rhamnose at the terminal of the sugar chain is also discussed.

Original languageEnglish (US)
Pages (from-to)1410-1414
Number of pages5
JournalPlanta Medica
Volume75
Issue number13
DOIs
StatePublished - Nov 17 2009

Keywords

  • Anti-atherosclerosis
  • Aquifoliaceae
  • Foam cells
  • Ilex kudingcha
  • Structure-activity relationship
  • Triterpenoid saponins

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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    Zheng, J., Tang, L., Xian, X. D., Zhou, S. X., Shi, H. M., Jiang, Y., Gu, Y. Q., Liu, G., & Tu, P. F. (2009). Inhibitory Effect of Triterpenoid Saponins from the Leaves of Ilex kudingcha on Aggregated LDL-Induced Lipid Deposition in Macrophages. Planta Medica, 75(13), 1410-1414. https://doi.org/10.1055/s-0029-1185722