Initial results from a prototype whole-body photon-counting computed tomography system

Z. Yu, S. Leng, S. M. Jorgensen, Z. Li, R. Gutjahr, B. Chen, X. Duan, A. F. Halaweish, L. Yu, E. L. Ritman, C. H. McCollough

Research output: Chapter in Book/Report/Conference proceedingConference contribution

35 Citations (Scopus)

Abstract

X-ray computed tomography (CT) with energy-discriminating capabilities presents exciting opportunities for increased dose efficiency and improved material decomposition analyses. However, due to constraints imposed by the inability of photon-counting detectors (PCD) to respond accurately at high photon flux, to date there has been no clinical application of PCD-CT. Recently, our lab installed a research prototype system consisting of two x-ray sources and two corresponding detectors, one using an energy-integrating detector (EID) and the other using a PCD. In this work, we report the first third-party evaluation of this prototype CT system using both phantoms and a cadaver head. The phantom studies demonstrated several promising characteristics of the PCD sub-system, including improved longitudinal spatial resolution and reduced beam hardening artifacts, relative to the EID sub-system. More importantly, we found that the PCD sub-system offers excellent pulse pileup control in cases of x-ray flux up to 550 mA at 140 kV, which corresponds to approximately 2.5×1011 photons per cm2 per second. In an anthropomorphic phantom and a cadaver head, the PCD sub-system provided image quality comparable to the EID sub-system for the same dose level. Our results demonstrate the potential of the prototype system to produce clinically-acceptable images in vivo.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2015: Physics of Medical Imaging
PublisherSPIE
Volume9412
ISBN (Print)9781628415025
DOIs
StatePublished - 2015
EventMedical Imaging 2015: Physics of Medical Imaging - Orlando, United States
Duration: Feb 22 2015Feb 25 2015

Other

OtherMedical Imaging 2015: Physics of Medical Imaging
CountryUnited States
CityOrlando
Period2/22/152/25/15

Fingerprint

Whole-Body Counting
Photons
Tomography
counting
tomography
prototypes
Detectors
detectors
photons
Cadaver
X rays
Head
X-Rays
X Ray Computed Tomography
Fluxes
dosage
Artifacts
energy
x ray sources
hardening

Keywords

  • Photon-counting CT
  • Research prototype
  • System evaluation

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Yu, Z., Leng, S., Jorgensen, S. M., Li, Z., Gutjahr, R., Chen, B., ... McCollough, C. H. (2015). Initial results from a prototype whole-body photon-counting computed tomography system. In Medical Imaging 2015: Physics of Medical Imaging (Vol. 9412). [94120W] SPIE. https://doi.org/10.1117/12.2082739

Initial results from a prototype whole-body photon-counting computed tomography system. / Yu, Z.; Leng, S.; Jorgensen, S. M.; Li, Z.; Gutjahr, R.; Chen, B.; Duan, X.; Halaweish, A. F.; Yu, L.; Ritman, E. L.; McCollough, C. H.

Medical Imaging 2015: Physics of Medical Imaging. Vol. 9412 SPIE, 2015. 94120W.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Yu, Z, Leng, S, Jorgensen, SM, Li, Z, Gutjahr, R, Chen, B, Duan, X, Halaweish, AF, Yu, L, Ritman, EL & McCollough, CH 2015, Initial results from a prototype whole-body photon-counting computed tomography system. in Medical Imaging 2015: Physics of Medical Imaging. vol. 9412, 94120W, SPIE, Medical Imaging 2015: Physics of Medical Imaging, Orlando, United States, 2/22/15. https://doi.org/10.1117/12.2082739
Yu Z, Leng S, Jorgensen SM, Li Z, Gutjahr R, Chen B et al. Initial results from a prototype whole-body photon-counting computed tomography system. In Medical Imaging 2015: Physics of Medical Imaging. Vol. 9412. SPIE. 2015. 94120W https://doi.org/10.1117/12.2082739
Yu, Z. ; Leng, S. ; Jorgensen, S. M. ; Li, Z. ; Gutjahr, R. ; Chen, B. ; Duan, X. ; Halaweish, A. F. ; Yu, L. ; Ritman, E. L. ; McCollough, C. H. / Initial results from a prototype whole-body photon-counting computed tomography system. Medical Imaging 2015: Physics of Medical Imaging. Vol. 9412 SPIE, 2015.
@inproceedings{3e38490d71924dda91709af7a7fa0bd6,
title = "Initial results from a prototype whole-body photon-counting computed tomography system",
abstract = "X-ray computed tomography (CT) with energy-discriminating capabilities presents exciting opportunities for increased dose efficiency and improved material decomposition analyses. However, due to constraints imposed by the inability of photon-counting detectors (PCD) to respond accurately at high photon flux, to date there has been no clinical application of PCD-CT. Recently, our lab installed a research prototype system consisting of two x-ray sources and two corresponding detectors, one using an energy-integrating detector (EID) and the other using a PCD. In this work, we report the first third-party evaluation of this prototype CT system using both phantoms and a cadaver head. The phantom studies demonstrated several promising characteristics of the PCD sub-system, including improved longitudinal spatial resolution and reduced beam hardening artifacts, relative to the EID sub-system. More importantly, we found that the PCD sub-system offers excellent pulse pileup control in cases of x-ray flux up to 550 mA at 140 kV, which corresponds to approximately 2.5×1011 photons per cm2 per second. In an anthropomorphic phantom and a cadaver head, the PCD sub-system provided image quality comparable to the EID sub-system for the same dose level. Our results demonstrate the potential of the prototype system to produce clinically-acceptable images in vivo.",
keywords = "Photon-counting CT, Research prototype, System evaluation",
author = "Z. Yu and S. Leng and Jorgensen, {S. M.} and Z. Li and R. Gutjahr and B. Chen and X. Duan and Halaweish, {A. F.} and L. Yu and Ritman, {E. L.} and McCollough, {C. H.}",
year = "2015",
doi = "10.1117/12.2082739",
language = "English (US)",
isbn = "9781628415025",
volume = "9412",
booktitle = "Medical Imaging 2015: Physics of Medical Imaging",
publisher = "SPIE",

}

TY - GEN

T1 - Initial results from a prototype whole-body photon-counting computed tomography system

AU - Yu, Z.

AU - Leng, S.

AU - Jorgensen, S. M.

AU - Li, Z.

AU - Gutjahr, R.

AU - Chen, B.

AU - Duan, X.

AU - Halaweish, A. F.

AU - Yu, L.

AU - Ritman, E. L.

AU - McCollough, C. H.

PY - 2015

Y1 - 2015

N2 - X-ray computed tomography (CT) with energy-discriminating capabilities presents exciting opportunities for increased dose efficiency and improved material decomposition analyses. However, due to constraints imposed by the inability of photon-counting detectors (PCD) to respond accurately at high photon flux, to date there has been no clinical application of PCD-CT. Recently, our lab installed a research prototype system consisting of two x-ray sources and two corresponding detectors, one using an energy-integrating detector (EID) and the other using a PCD. In this work, we report the first third-party evaluation of this prototype CT system using both phantoms and a cadaver head. The phantom studies demonstrated several promising characteristics of the PCD sub-system, including improved longitudinal spatial resolution and reduced beam hardening artifacts, relative to the EID sub-system. More importantly, we found that the PCD sub-system offers excellent pulse pileup control in cases of x-ray flux up to 550 mA at 140 kV, which corresponds to approximately 2.5×1011 photons per cm2 per second. In an anthropomorphic phantom and a cadaver head, the PCD sub-system provided image quality comparable to the EID sub-system for the same dose level. Our results demonstrate the potential of the prototype system to produce clinically-acceptable images in vivo.

AB - X-ray computed tomography (CT) with energy-discriminating capabilities presents exciting opportunities for increased dose efficiency and improved material decomposition analyses. However, due to constraints imposed by the inability of photon-counting detectors (PCD) to respond accurately at high photon flux, to date there has been no clinical application of PCD-CT. Recently, our lab installed a research prototype system consisting of two x-ray sources and two corresponding detectors, one using an energy-integrating detector (EID) and the other using a PCD. In this work, we report the first third-party evaluation of this prototype CT system using both phantoms and a cadaver head. The phantom studies demonstrated several promising characteristics of the PCD sub-system, including improved longitudinal spatial resolution and reduced beam hardening artifacts, relative to the EID sub-system. More importantly, we found that the PCD sub-system offers excellent pulse pileup control in cases of x-ray flux up to 550 mA at 140 kV, which corresponds to approximately 2.5×1011 photons per cm2 per second. In an anthropomorphic phantom and a cadaver head, the PCD sub-system provided image quality comparable to the EID sub-system for the same dose level. Our results demonstrate the potential of the prototype system to produce clinically-acceptable images in vivo.

KW - Photon-counting CT

KW - Research prototype

KW - System evaluation

UR - http://www.scopus.com/inward/record.url?scp=84943329442&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84943329442&partnerID=8YFLogxK

U2 - 10.1117/12.2082739

DO - 10.1117/12.2082739

M3 - Conference contribution

C2 - 26097280

AN - SCOPUS:84943329442

SN - 9781628415025

VL - 9412

BT - Medical Imaging 2015: Physics of Medical Imaging

PB - SPIE

ER -