Initiation of human parturition. IV. Demonstration of phospholipase A2 in the lysosomes of human fetal membranes

Barry E. Schwarz, F. Michael Schultz, Paul C. MacDonald, John M. Johnston

Research output: Contribution to journalArticle

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Abstract

In this study we sought to define the subcellular localization of phospholipase A2 in human fetal membranes. Others have postulated a role for decidual lysosomes in the initiation of human parturition.5 We hypothesized that if phospholipase A2 were localized within lysosomes of fetal membranes the accelerated expression of the activity of this enzyme could be prevented until such time as the metabolic events of parturition begin. At parturition a perturbation of the lysosomal membrane within the chorio-amnion could result in an increased release of free arachidonic acid through an accelerated activity of phospholipase A2. The results of this study suggest that at least a portion of phospholipase A2 in the chorion laeve and amnion is localized in the lysosomal fraction.

Original languageEnglish (US)
Pages (from-to)1089-1092
Number of pages4
JournalAmerican journal of obstetrics and gynecology
Volume125
Issue number8
DOIs
StatePublished - Aug 15 1976

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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