Initiation of human parturition. IX. Progesterone metabolism by placentas of early and late human gestation

L. Milewich, N. F. Gant, B. E. Schwarz, G. T. Chen, P. C. Macdonald

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Abstract

In in vitro studies it was found that, in the presence of added NADPH, the human placenta metabolizes progesterone to 20α-hydroxy-4-pregnen-3-one at increasing rates as pregnancy advances. A fivefold increase in 20α-hydroxysteroid oxidoreductase activity is observed in term placentas compared with the enzymic activity of placentas of 12 to 20 wk gestation (368 ± 53 pmoles/mg protein/hr vs 71 ± 8pmoles/mg protein/hr). The 5α-reductase and 3β-hydroxysteroid oxidoreductase activities were similar in placentas obtained from early and late human pregnancies.

Original languageEnglish (US)
Pages (from-to)278-280
Number of pages3
JournalObstetrics and Gynecology
Volume51
Issue number3
Publication statusPublished - 1978

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ASJC Scopus subject areas

  • Obstetrics and Gynecology

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