Initiation of human parturition. V. Progesterone binding substance in fetal membranes

B. E. Schwarz, L. Milewich, J. M. Johnston, J. C. Porter, P. C. MacDonald

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

This study was undertaken as part of an investigation of the potential role of progesterone metabolism within fetal membranes in the initiation of human labor. The results of this study provide evidence that a progesterone binding substance is present in amnion and chorion laeve during the last few days of pregnancy. This substance binds progesterone, cortisol, and 5α dihydroprogesterone but does not bind 20α hydroxy 4 pregnen 3 one, R 5020, or dexamethasone. We conclude that this is a previously undescribed progesterone binding substance and propose a possible mechanism by which this substance may be involved in the initiation of human parturition.

Original languageEnglish (US)
Pages (from-to)685-689
Number of pages5
JournalObstetrics and Gynecology
Volume48
Issue number6
StatePublished - 1976

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Extraembryonic Membranes
Progesterone
Parturition
20-alpha-Dihydroprogesterone
Promegestone
Chorion
Amnion
Dexamethasone
Hydrocortisone
Pregnancy

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Schwarz, B. E., Milewich, L., Johnston, J. M., Porter, J. C., & MacDonald, P. C. (1976). Initiation of human parturition. V. Progesterone binding substance in fetal membranes. Obstetrics and Gynecology, 48(6), 685-689.

Initiation of human parturition. V. Progesterone binding substance in fetal membranes. / Schwarz, B. E.; Milewich, L.; Johnston, J. M.; Porter, J. C.; MacDonald, P. C.

In: Obstetrics and Gynecology, Vol. 48, No. 6, 1976, p. 685-689.

Research output: Contribution to journalArticle

Schwarz, BE, Milewich, L, Johnston, JM, Porter, JC & MacDonald, PC 1976, 'Initiation of human parturition. V. Progesterone binding substance in fetal membranes', Obstetrics and Gynecology, vol. 48, no. 6, pp. 685-689.
Schwarz, B. E. ; Milewich, L. ; Johnston, J. M. ; Porter, J. C. ; MacDonald, P. C. / Initiation of human parturition. V. Progesterone binding substance in fetal membranes. In: Obstetrics and Gynecology. 1976 ; Vol. 48, No. 6. pp. 685-689.
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