Injury-induced neurogenesis in Bax-deficient mice: Evidence for regulation by voltage-gated potassium channels

Jian Shi, Darryl K. Miles, Benjamin A. Orr, Stephen M. Massa, Steven G. Kernie

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Adult neural stem and progenitor cells may help remodel the brain in response to injury. The pro-apoptotic molecule Bax has recently been identified as a key player in adult neural stem cell survival. In Bax-deficient mice that have undergone traumatic brain injury, we find increased numbers of neural progenitor cells in the dentate gyrus and improved remodeling of the hippocampus. Exogenous potassium chloride mimics spreading depression (SD)-like events in vitro, and Bax-deficient neural stem cells proliferate in response to these events more robustly than wild-type neural stem cells. Selective potassium channel blockers interrupt SD-mediated stimulation of stem cells. In addition, the potassium channel Kv4.1 is expressed within neural stem and progenitor cells in the dentate gyrus and is increased in Bax-deficiency. These data suggest that the neuroprotection observed after injury in Bax-deficiency may be due to increased neurogenesis via activation of the Kv4 family of potassium channels.

Original languageEnglish (US)
Pages (from-to)3499-3512
Number of pages14
JournalEuropean Journal of Neuroscience
Volume25
Issue number12
DOIs
StatePublished - Jun 2007

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Voltage-Gated Potassium Channels
Neural Stem Cells
Neurogenesis
Shal Potassium Channels
Stem Cells
Wounds and Injuries
Adult Stem Cells
Dentate Gyrus
Potassium Channel Blockers
Potassium Chloride
Hippocampus
Cell Survival
Brain

Keywords

  • Apoptosis
  • Calcium
  • Caspase
  • Dentate gyrus
  • Neural stem cell

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Injury-induced neurogenesis in Bax-deficient mice : Evidence for regulation by voltage-gated potassium channels. / Shi, Jian; Miles, Darryl K.; Orr, Benjamin A.; Massa, Stephen M.; Kernie, Steven G.

In: European Journal of Neuroscience, Vol. 25, No. 12, 06.2007, p. 3499-3512.

Research output: Contribution to journalArticle

Shi, Jian ; Miles, Darryl K. ; Orr, Benjamin A. ; Massa, Stephen M. ; Kernie, Steven G. / Injury-induced neurogenesis in Bax-deficient mice : Evidence for regulation by voltage-gated potassium channels. In: European Journal of Neuroscience. 2007 ; Vol. 25, No. 12. pp. 3499-3512.
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