Injury-stimulated and self-restrained BMP signaling dynamically regulates stem cell pool size during Drosophila midgut regeneration

Aiguo Tian, Bing Wang, Jin Jiang

Research output: Contribution to journalArticle

12 Scopus citations


Many adult organs rely on resident stem cells to maintain homeostasis. Upon injury, stem cells increase proliferation, followed by lineage differentiation to replenish damaged cells. Whether stem cells also change division mode to transiently increase their population size as part of a regenerative program and, if so, what the underlying mechanism is have remained largely unexplored. Here we show that injury stimulates the production of two bone morphogenetic protein (BMP) ligands, Dpp and Gbb, which drive an expansion of intestinal stem cells (ISCs) by promoting their symmetric self-renewing division in Drosophila adult midgut. We find that BMP production in enterocytes is inhibited by BMP signaling itself, and that BMP autoinhibition is required for resetting ISC pool size to the homeostatic level after tissue repair. Our study suggests that dynamic BMP signaling controls ISC population size during midgut regeneration and reveals mechanisms that precisely control stem cell number in response to tissue needs.

Original languageEnglish (US)
Pages (from-to)E2699-E2708
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number13
Publication statusPublished - Mar 28 2017



  • BMP
  • Dpp
  • Midgut
  • Regeneration
  • Stem Cell

ASJC Scopus subject areas

  • General

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