Innate control of adaptive immunity: Beyond the three-signal paradigm

Aakanksha Jain, Chandrashekhar Pasare

Research output: Contribution to journalReview article

39 Scopus citations

Abstract

Activation of cells in the adaptive immune system is a highly orchestrated process dictated by multiples cues from the innate immune system. Although the fundamental principles of innate control of adaptive immunity are well established, it is not fully understood how innate cells integrate qualitative pathogenic information to generate tailored protective adaptive immune responses. In this review, we discuss complexities involved in the innate control of adaptive immunity that extend beyond TCR engagement, costimulation, and priming cytokine production but are critical for the generation of protective T cell immunity.

Original languageEnglish (US)
Pages (from-to)3791-3800
Number of pages10
JournalJournal of Immunology
Volume198
Issue number10
DOIs
StatePublished - May 15 2017

ASJC Scopus subject areas

  • Immunology

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