Innate immunity: An overview

Bruce Beutler

doi:10.1016/j.molimm.2003.10.005

Innate immunity: An overview

Bruce Beutler

Research output: Contribution to journal › Article › peer-review

931 Scopus citations

Abstract

Though sometimes portrayed as "new," the science of innate immunity made its start more than 100 years ago. Recent progress has reflected the application of new methods to old problems. In particular, genetic dissection of innate immune pathways has been pursued with great success in model organisms. This has opened the way to an understanding of innate immune sensing. The effector arm of innate immunity has also been tackled, largely though the use of biochemical methods.

Original language	English (US)
Pages (from-to)	845-859
Number of pages	15
Journal	Molecular Immunology
Volume	40
Issue number	12
DOIs	https://doi.org/10.1016/j.molimm.2003.10.005
State	Published - Feb 2004

Keywords

Infection
Innate immunity
Lipopolysaccharide
Sepsis
TIR adapter proteins
Toll like receptors

ASJC Scopus subject areas

Immunology
Molecular Biology

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10.1016/j.molimm.2003.10.005

Cite this

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keywords = "Infection, Innate immunity, Lipopolysaccharide, Sepsis, TIR adapter proteins, Toll like receptors",

author = "Bruce Beutler",

note = "Funding Information: This work was supported by the following NIH grants: 1R01-GM60031, U54-AI54523, 5P01-AI140682. ",

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KW - Lipopolysaccharide

KW - Sepsis

KW - TIR adapter proteins

KW - Toll like receptors

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Innate immunity: An overview

Abstract

Keywords

ASJC Scopus subject areas

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