Innate immunity in inflammatory bowel disease

Jesus K. Yamamoto-Furusho, Daniel K. Podolsky

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

The human intestinal tract is home to an enormous bacterial flora. The host defense against microorganisms can be divided into innate and adaptive immunity. The former is the most immediate line of response to immunologic challenges presented by bacteria, viruses, and fungi. The mucosal immune system has evolved to balance the need to respond to pathogens while co-existing with commensal bacteria and food antigens. In inflammatory bowel disease (IBD), this hyporesponsiveness or tolerance breaks down and inflammation supervenes driven by the intestinal microbial flora. Bacteria contain compounds and are recognized by a variety of receptors, including Toll-like receptors (TLRs) and NODs (a family of intracellular bacterial sensors) and are potent stimuli of innate immune responses. Several mutations in these receptors have been associated with development of IBD.

Original languageEnglish (US)
Pages (from-to)5577-5580
Number of pages4
JournalWorld Journal of Gastroenterology
Volume13
Issue number42
StatePublished - Nov 14 2007

Fingerprint

Inflammatory Bowel Diseases
Innate Immunity
Bacteria
Toll-Like Receptors
Adaptive Immunity
Immune System
Fungi
Viruses
Inflammation
Antigens
Food
Mutation

Keywords

  • Immunity
  • Inflammatory bowel disease
  • Innate
  • Toll-like receptors

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Innate immunity in inflammatory bowel disease. / Yamamoto-Furusho, Jesus K.; Podolsky, Daniel K.

In: World Journal of Gastroenterology, Vol. 13, No. 42, 14.11.2007, p. 5577-5580.

Research output: Contribution to journalArticle

Yamamoto-Furusho, JK & Podolsky, DK 2007, 'Innate immunity in inflammatory bowel disease', World Journal of Gastroenterology, vol. 13, no. 42, pp. 5577-5580.
Yamamoto-Furusho, Jesus K. ; Podolsky, Daniel K. / Innate immunity in inflammatory bowel disease. In: World Journal of Gastroenterology. 2007 ; Vol. 13, No. 42. pp. 5577-5580.
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