TY - JOUR
T1 - Innate immunity in inflammatory bowel disease
AU - Yamamoto-Furusho, Jesus K.
AU - Podolsky, Daniel K.
PY - 2007/11/14
Y1 - 2007/11/14
N2 - The human intestinal tract is home to an enormous bacterial flora. The host defense against microorganisms can be divided into innate and adaptive immunity. The former is the most immediate line of response to immunologic challenges presented by bacteria, viruses, and fungi. The mucosal immune system has evolved to balance the need to respond to pathogens while co-existing with commensal bacteria and food antigens. In inflammatory bowel disease (IBD), this hyporesponsiveness or tolerance breaks down and inflammation supervenes driven by the intestinal microbial flora. Bacteria contain compounds and are recognized by a variety of receptors, including Toll-like receptors (TLRs) and NODs (a family of intracellular bacterial sensors) and are potent stimuli of innate immune responses. Several mutations in these receptors have been associated with development of IBD.
AB - The human intestinal tract is home to an enormous bacterial flora. The host defense against microorganisms can be divided into innate and adaptive immunity. The former is the most immediate line of response to immunologic challenges presented by bacteria, viruses, and fungi. The mucosal immune system has evolved to balance the need to respond to pathogens while co-existing with commensal bacteria and food antigens. In inflammatory bowel disease (IBD), this hyporesponsiveness or tolerance breaks down and inflammation supervenes driven by the intestinal microbial flora. Bacteria contain compounds and are recognized by a variety of receptors, including Toll-like receptors (TLRs) and NODs (a family of intracellular bacterial sensors) and are potent stimuli of innate immune responses. Several mutations in these receptors have been associated with development of IBD.
KW - Immunity
KW - Inflammatory bowel disease
KW - Innate
KW - Toll-like receptors
UR - http://www.scopus.com/inward/record.url?scp=35649026321&partnerID=8YFLogxK
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U2 - 10.3748/wjg.v13.i42.5577
DO - 10.3748/wjg.v13.i42.5577
M3 - Article
C2 - 17948931
AN - SCOPUS:35649026321
SN - 1007-9327
VL - 13
SP - 5577
EP - 5580
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
IS - 42
ER -