Inner ear histopathology in patients treated with cis-platinum

C. G. Wright, S. D. Schaefer

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

Temporal bone histopathology was studied in five patients (aged 51-67) who received cis-diamminedichloroplatinum (DDP) chemotherapy for head and neck squamous cell carcinoma. In each case, a sensorineural hearing loss occurred during the course of treatment and temporal bones were acquired 3-5 hours postmortem for anatomical study. Scanning electron microscopy revealed acute degenerative changes in cochlear hair cells that appeared to be the result of drug treatment. However, the presence of age-related degeneration made it difficult to unequivocally identify hair cell loss due solely to ototoxicity. In one patient, a decrement in vestibular function was observed during DDP treatment. Postmortem examination showed severe degeneration of the maculae and cristae which could be correlated with the absence of caloric response seen after chemotherapy.

Original languageEnglish (US)
Pages (from-to)1408-1413
Number of pages6
JournalLaryngoscope
Volume92
Issue number12
StatePublished - 1982

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Inner Ear
Cisplatin
Temporal Bone
Auditory Hair Cells
Drug Therapy
Sensorineural Hearing Loss
Alopecia
Electron Scanning Microscopy
Autopsy
Therapeutics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Wright, C. G., & Schaefer, S. D. (1982). Inner ear histopathology in patients treated with cis-platinum. Laryngoscope, 92(12), 1408-1413.

Inner ear histopathology in patients treated with cis-platinum. / Wright, C. G.; Schaefer, S. D.

In: Laryngoscope, Vol. 92, No. 12, 1982, p. 1408-1413.

Research output: Contribution to journalArticle

Wright, CG & Schaefer, SD 1982, 'Inner ear histopathology in patients treated with cis-platinum', Laryngoscope, vol. 92, no. 12, pp. 1408-1413.
Wright CG, Schaefer SD. Inner ear histopathology in patients treated with cis-platinum. Laryngoscope. 1982;92(12):1408-1413.
Wright, C. G. ; Schaefer, S. D. / Inner ear histopathology in patients treated with cis-platinum. In: Laryngoscope. 1982 ; Vol. 92, No. 12. pp. 1408-1413.
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