Inositol 1,4,5-trisphosphate receptors and neurodegenerative disorders

Polina A. Egorova, Ilya B. Bezprozvanny

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations

Abstract

The inositol 1,4,5-trisphosphate receptor (IP3R) is an intracellular ion channel that mediates the release of calcium ions from the endoplasmic reticulum. It plays a role in basic biological functions, such as cell division, differentiation, fertilization and cell death, and is involved in developmental processes including learning, memory and behavior. Deregulation of neuronal calcium signaling results in disturbance of cell homeostasis, synaptic loss and dysfunction, eventually leading to cell death. Three IP3R subtypes have been identified in mammalian cells and the predominant isoform in neurons is IP3R type 1. Dysfunction of IP3R type 1 may play a role in the pathogenesis of certain neurodegenerative diseases as enhanced activity of the IP3R was observed in models of Huntington's disease, spinocerebellar ataxias and Alzheimer's disease. These results suggest that IP3R-mediated signaling is a potential target for treatment of these disorders. In this review we discuss the structure, functions and regulation of the IP3R in healthy neurons and in conditions of neurodegeneration.

Original languageEnglish (US)
Pages (from-to)3547-3565
Number of pages19
JournalFEBS Journal
Volume285
Issue number19
DOIs
StatePublished - Oct 2018

Keywords

  • calcium signaling
  • inositol 1,4,5-trisphosphate receptor
  • neurodegenerative diseases
  • neuronal loss
  • polyglutamine disorders

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Inositol 1,4,5-trisphosphate receptors and neurodegenerative disorders'. Together they form a unique fingerprint.

Cite this