Inotropic effects of activation and pharmacological mechanisms in cardiac muscle

H. Joachim Mensing, Donald W. Hilgemann

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

'Staircase' phenomena in heart muscle simply reflect changes of the amount of calcium at its release sites according to textbook explanations. Available evidence, however, implicates intracellular sodium and the sodium pump as well as cyclic AMP and enzymes involved in regulatory protein phosphorylation in potentiation phenomena. A better understanding of these mechanisms can be an important aid in the investigation of cardioactive drugs and possibly will be relevant in related areas of research, such as electro-secretory coupling and neurophysiology.

Original languageEnglish (US)
Pages (from-to)303-307
Number of pages5
JournalTrends in Pharmacological Sciences
Volume2
Issue numberC
DOIs
StatePublished - 1981

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

Fingerprint Dive into the research topics of 'Inotropic effects of activation and pharmacological mechanisms in cardiac muscle'. Together they form a unique fingerprint.

  • Cite this