Inotropic effects of activation and pharmacological mechanisms in cardiac muscle

H. Joachim Mensing, Donald W. Hilgemann

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

'Staircase' phenomena in heart muscle simply reflect changes of the amount of calcium at its release sites according to textbook explanations. Available evidence, however, implicates intracellular sodium and the sodium pump as well as cyclic AMP and enzymes involved in regulatory protein phosphorylation in potentiation phenomena. A better understanding of these mechanisms can be an important aid in the investigation of cardioactive drugs and possibly will be relevant in related areas of research, such as electro-secretory coupling and neurophysiology.

Original languageEnglish (US)
Pages (from-to)303-307
Number of pages5
JournalTrends in Pharmacological Sciences
Volume2
Issue numberC
DOIs
StatePublished - 1981

Fingerprint

Neurophysiology
Sodium-Potassium-Exchanging ATPase
Phosphorylation
Textbooks
Cyclic AMP
Muscle
Myocardium
Sodium
Chemical activation
Pharmacology
Calcium
Enzymes
Research
Pharmaceutical Preparations
Proteins

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Inotropic effects of activation and pharmacological mechanisms in cardiac muscle. / Joachim Mensing, H.; Hilgemann, Donald W.

In: Trends in Pharmacological Sciences, Vol. 2, No. C, 1981, p. 303-307.

Research output: Contribution to journalArticle

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