TY - JOUR
T1 - Inotropic effects of activation and pharmacological mechanisms in cardiac muscle
AU - Joachim Mensing, H.
AU - Hilgemann, Donald W.
PY - 1981
Y1 - 1981
N2 - 'Staircase' phenomena in heart muscle simply reflect changes of the amount of calcium at its release sites according to textbook explanations. Available evidence, however, implicates intracellular sodium and the sodium pump as well as cyclic AMP and enzymes involved in regulatory protein phosphorylation in potentiation phenomena. A better understanding of these mechanisms can be an important aid in the investigation of cardioactive drugs and possibly will be relevant in related areas of research, such as electro-secretory coupling and neurophysiology.
AB - 'Staircase' phenomena in heart muscle simply reflect changes of the amount of calcium at its release sites according to textbook explanations. Available evidence, however, implicates intracellular sodium and the sodium pump as well as cyclic AMP and enzymes involved in regulatory protein phosphorylation in potentiation phenomena. A better understanding of these mechanisms can be an important aid in the investigation of cardioactive drugs and possibly will be relevant in related areas of research, such as electro-secretory coupling and neurophysiology.
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U2 - 10.1016/0165-6147(81)90348-5
DO - 10.1016/0165-6147(81)90348-5
M3 - Article
AN - SCOPUS:8244230729
SN - 0165-6147
VL - 2
SP - 303
EP - 307
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
IS - C
ER -