Inotropic effects of activation and pharmacological mechanisms in cardiac muscle

H. Joachim Mensing, Donald W. Hilgemann

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


'Staircase' phenomena in heart muscle simply reflect changes of the amount of calcium at its release sites according to textbook explanations. Available evidence, however, implicates intracellular sodium and the sodium pump as well as cyclic AMP and enzymes involved in regulatory protein phosphorylation in potentiation phenomena. A better understanding of these mechanisms can be an important aid in the investigation of cardioactive drugs and possibly will be relevant in related areas of research, such as electro-secretory coupling and neurophysiology.

Original languageEnglish (US)
Pages (from-to)303-307
Number of pages5
JournalTrends in Pharmacological Sciences
Issue numberC
StatePublished - 1981

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology


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