Insights into the evolution of longevity from the bowhead whale genome

Michael Keane, Jeremy Semeiks, Andrew E. Webb, Yang I. Li, Víctor Quesada, Thomas Craig, Lone Bruhn Madsen, Sipko van Dam, David Brawand, Patrícia I. Marques, Pawel Michalak, Lin Kang, Jong Bhak, Hyung Soon Yim, Nick V. Grishin, Nynne Hjort Nielsen, Mads Peter Heide-Jørgensen, Elias M. Oziolor, Cole W. Matson, George M. Church & 10 others Gary W. Stuart, John C. Patton, J. Craig George, Robert Suydam, Knud Larsen, Carlos López-Otín, Mary J. O'Connell, John W. Bickham, Bo Thomsen, JoãoPedro P. deMagalhães

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

The bowhead whale (Balaena mysticetus) is estimated to live over 200 years and is possibly thelongest-living mammal. These animals should possess protective molecular adaptations relevant to age-related diseases, particularly cancer. Here, we report the sequencing and comparative analysis of the bowhead whale genome and two transcriptomes from different populations. Our analysis identifies genes under positive selection and bowhead-specific mutations in genes linked to cancer and aging. In addition, we identify gene gain and loss involving genes associated with DNA repair, cell-cycle regulation, cancer, and aging. Our results expand our understanding of the evolution of mammalian longevity and suggest possible players involved in adaptive genetic changes conferring cancer resistance. We also found potentially relevant changes in genes related to additional processes, including thermoregulation, sensory perception, dietary adaptations, and immune response. Our data are made available online (http://www.bowhead-whale.org) to facilitate research in this long-lived species.

Original languageEnglish (US)
Pages (from-to)112-122
Number of pages11
JournalCell Reports
Volume10
Issue number1
DOIs
StatePublished - Jan 6 2015

Fingerprint

Bowhead Whale
Genes
Genome
Neoplasms
Aging of materials
Body Temperature Regulation
Mammals
Transcriptome
DNA Repair
Cell Cycle
Animals
Repair
Cells
Mutation
Research
DNA
Population

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Keane, M., Semeiks, J., Webb, A. E., Li, Y. I., Quesada, V., Craig, T., ... deMagalhães, J. P. (2015). Insights into the evolution of longevity from the bowhead whale genome. Cell Reports, 10(1), 112-122. https://doi.org/10.1016/j.celrep.2014.12.008

Insights into the evolution of longevity from the bowhead whale genome. / Keane, Michael; Semeiks, Jeremy; Webb, Andrew E.; Li, Yang I.; Quesada, Víctor; Craig, Thomas; Madsen, Lone Bruhn; van Dam, Sipko; Brawand, David; Marques, Patrícia I.; Michalak, Pawel; Kang, Lin; Bhak, Jong; Yim, Hyung Soon; Grishin, Nick V.; Nielsen, Nynne Hjort; Heide-Jørgensen, Mads Peter; Oziolor, Elias M.; Matson, Cole W.; Church, George M.; Stuart, Gary W.; Patton, John C.; George, J. Craig; Suydam, Robert; Larsen, Knud; López-Otín, Carlos; O'Connell, Mary J.; Bickham, John W.; Thomsen, Bo; deMagalhães, JoãoPedro P.

In: Cell Reports, Vol. 10, No. 1, 06.01.2015, p. 112-122.

Research output: Contribution to journalArticle

Keane, M, Semeiks, J, Webb, AE, Li, YI, Quesada, V, Craig, T, Madsen, LB, van Dam, S, Brawand, D, Marques, PI, Michalak, P, Kang, L, Bhak, J, Yim, HS, Grishin, NV, Nielsen, NH, Heide-Jørgensen, MP, Oziolor, EM, Matson, CW, Church, GM, Stuart, GW, Patton, JC, George, JC, Suydam, R, Larsen, K, López-Otín, C, O'Connell, MJ, Bickham, JW, Thomsen, B & deMagalhães, JP 2015, 'Insights into the evolution of longevity from the bowhead whale genome', Cell Reports, vol. 10, no. 1, pp. 112-122. https://doi.org/10.1016/j.celrep.2014.12.008
Keane M, Semeiks J, Webb AE, Li YI, Quesada V, Craig T et al. Insights into the evolution of longevity from the bowhead whale genome. Cell Reports. 2015 Jan 6;10(1):112-122. https://doi.org/10.1016/j.celrep.2014.12.008
Keane, Michael ; Semeiks, Jeremy ; Webb, Andrew E. ; Li, Yang I. ; Quesada, Víctor ; Craig, Thomas ; Madsen, Lone Bruhn ; van Dam, Sipko ; Brawand, David ; Marques, Patrícia I. ; Michalak, Pawel ; Kang, Lin ; Bhak, Jong ; Yim, Hyung Soon ; Grishin, Nick V. ; Nielsen, Nynne Hjort ; Heide-Jørgensen, Mads Peter ; Oziolor, Elias M. ; Matson, Cole W. ; Church, George M. ; Stuart, Gary W. ; Patton, John C. ; George, J. Craig ; Suydam, Robert ; Larsen, Knud ; López-Otín, Carlos ; O'Connell, Mary J. ; Bickham, John W. ; Thomsen, Bo ; deMagalhães, JoãoPedro P. / Insights into the evolution of longevity from the bowhead whale genome. In: Cell Reports. 2015 ; Vol. 10, No. 1. pp. 112-122.
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