Insights into the Irritating Mechanisms of TRPA1 Revealed by Cryo-EM

Research output: Contribution to journalArticlepeer-review

Abstract

TRPA1 is a promising target for the development of novel treatments for chronic pain. In this issue of Neuron, Liu et al. (2021) report a novel non-covalent TRPA1-biased agonist, GNE551, revealing a unique binding pocket by cryo-EM and activation properties that pave a path toward new avenues in the treatment of chronic pain.

Original languageEnglish (US)
Pages (from-to)194-196
Number of pages3
JournalNeuron
Volume109
Issue number2
DOIs
StatePublished - Jan 20 2021

ASJC Scopus subject areas

  • Neuroscience(all)

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