Insulin and the burned patient

Heather F. Pidcoke; Charles E. Wade; Steven E. Wolf

doi:10.1097/01.CCM.0000278065.72486.31

Insulin and the burned patient

Heather F. Pidcoke, Charles E. Wade, Steven E. Wolf

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Severe burns lead to insulin resistance, which is associated with hyperglycemia and muscle wasting. Investigators showed relatively recently that control of hyperglycemia with intensive insulin treatment is associated with improved outcomes for those in the intensive care unit, including patients with severe burns. In this article, we review the actions of insulin in terms of glycemic control and muscle metabolism, biochemical and clinical effects of insulin treatment in the severely burned, and the vagaries of glucose control.

Original language	English (US)
Pages (from-to)	S524-S530
Journal	Critical care medicine
Volume	35
Issue number	9 SUPPL.
DOIs	https://doi.org/10.1097/01.CCM.0000278065.72486.31
State	Published - Sep 2007

Keywords

Burns
Glycemic control
Insulin resistance
Muscle metabolism
Muscle wasting

ASJC Scopus subject areas

Critical Care and Intensive Care Medicine

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10.1097/01.CCM.0000278065.72486.31

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title = "Insulin and the burned patient",

abstract = "Severe burns lead to insulin resistance, which is associated with hyperglycemia and muscle wasting. Investigators showed relatively recently that control of hyperglycemia with intensive insulin treatment is associated with improved outcomes for those in the intensive care unit, including patients with severe burns. In this article, we review the actions of insulin in terms of glycemic control and muscle metabolism, biochemical and clinical effects of insulin treatment in the severely burned, and the vagaries of glucose control.",

keywords = "Burns, Glycemic control, Insulin resistance, Muscle metabolism, Muscle wasting",

author = "Pidcoke, {Heather F.} and Wade, {Charles E.} and Wolf, {Steven E.}",

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AU - Pidcoke, Heather F.

AU - Wade, Charles E.

AU - Wolf, Steven E.

N1 - Funding Information: Supported, in part, by grant 1 R01 GM063120-04 from the National Institutes of Health, Bethesda, MD.

PY - 2007/9

Y1 - 2007/9

N2 - Severe burns lead to insulin resistance, which is associated with hyperglycemia and muscle wasting. Investigators showed relatively recently that control of hyperglycemia with intensive insulin treatment is associated with improved outcomes for those in the intensive care unit, including patients with severe burns. In this article, we review the actions of insulin in terms of glycemic control and muscle metabolism, biochemical and clinical effects of insulin treatment in the severely burned, and the vagaries of glucose control.

AB - Severe burns lead to insulin resistance, which is associated with hyperglycemia and muscle wasting. Investigators showed relatively recently that control of hyperglycemia with intensive insulin treatment is associated with improved outcomes for those in the intensive care unit, including patients with severe burns. In this article, we review the actions of insulin in terms of glycemic control and muscle metabolism, biochemical and clinical effects of insulin treatment in the severely burned, and the vagaries of glucose control.

KW - Burns

KW - Glycemic control

KW - Insulin resistance

KW - Muscle metabolism

KW - Muscle wasting

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Insulin and the burned patient

Abstract

Keywords

ASJC Scopus subject areas

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