Insulin degludec/liraglutide (IDegLira) was effective across a range of dysglycaemia and body mass index categories in the DUAL V randomized trial

Ildiko Lingvay, Stewart Harris, Elmar Jaeckel, Keval Chandarana, Mattis F. Ranthe, Esteban Jódar

Research output: Contribution to journal › Article

2 Citations (Scopus)

Abstract

This study assessed the efficacy of insulin degludec/liraglutide (IDegLira) vs insulin glargine U100 (IGlar) across categories of baseline glycated haemoglobin (HbA1c; ≤7.5%, >7.5% to ≤8.5% and >8.5%), body mass index (BMI; <30, ≥30 to <35 and ≥35kg/m2) and fasting plasma glucose (FPG; <7.2 and ≥7.2mmol/L) in patients with type 2 diabetes (T2D) uncontrolled on basal insulin, using post hoc analyses of the DUAL V 26-week trial. With IDegLira, mean HbA1c was reduced across all baseline HbA1c (1.0%-2.5%), FPG (1.5%-1.9%) and BMI categories (1.8%-1.9%), with significantly greater reductions compared with IGlar U100. For all HbA1c, FPG and BMI categories, IDegLira resulted in weight loss and IGlar U100 in weight gain; hypoglycaemia rates were lower for IDegLira vs IGlar U100. More patients achieved HbA1c <7% with IDegLira than IGlar U100 across all HbA1c (59%-87% vs 31%-66%), FPG (71%-74% vs 40%-51%) and BMI categories (71%-73% vs 40%-54%). IDegLira improved glycaemic control and induced weight loss in patients with T2D previously uncontrolled on basal insulin, across the categories of baseline HbA1c, FPG or BMI that were tested.

Original languageEnglish (US)
JournalDiabetes, Obesity and Metabolism
DOIs
StateAccepted/In press - 2017

Fingerprint

Body Mass Index
Type 2 Diabetes Mellitus
Weight Loss
Insulin
Glycosylated Hemoglobin A
Hypoglycemia
Weight Gain
Liraglutide
insulin degludec
Fasting
Insulin Glargine
Glucose

Keywords

  • IDegLira
  • Body mass index
  • Clinical trial
  • Insulin therapy
  • Type 2 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Insulin degludec/liraglutide (IDegLira) was effective across a range of dysglycaemia and body mass index categories in the DUAL V randomized trial. / Lingvay, Ildiko; Harris, Stewart; Jaeckel, Elmar; Chandarana, Keval; Ranthe, Mattis F.; Jódar, Esteban.

In: Diabetes, Obesity and Metabolism, 2017.

Research output: Contribution to journal › Article

Lingvay, I, Harris, S, Jaeckel, E, Chandarana, K, Ranthe, MF & Jódar, E 2017, 'Insulin degludec/liraglutide (IDegLira) was effective across a range of dysglycaemia and body mass index categories in the DUAL V randomized trial', Diabetes, Obesity and Metabolism. https://doi.org/10.1111/dom.13043
Lingvay I, Harris S, Jaeckel E, Chandarana K, Ranthe MF, Jódar E. Insulin degludec/liraglutide (IDegLira) was effective across a range of dysglycaemia and body mass index categories in the DUAL V randomized trial. Diabetes, Obesity and Metabolism. 2017. https://doi.org/10.1111/dom.13043
Lingvay, Ildiko ; Harris, Stewart ; Jaeckel, Elmar ; Chandarana, Keval ; Ranthe, Mattis F. ; Jódar, Esteban. / Insulin degludec/liraglutide (IDegLira) was effective across a range of dysglycaemia and body mass index categories in the DUAL V randomized trial. In: Diabetes, Obesity and Metabolism. 2017.
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abstract = "This study assessed the efficacy of insulin degludec/liraglutide (IDegLira) vs insulin glargine U100 (IGlar) across categories of baseline glycated haemoglobin (HbA1c; ≤7.5{\%}, >7.5{\%} to ≤8.5{\%} and >8.5{\%}), body mass index (BMI; <30, ≥30 to <35 and ≥35kg/m2) and fasting plasma glucose (FPG; <7.2 and ≥7.2mmol/L) in patients with type 2 diabetes (T2D) uncontrolled on basal insulin, using post hoc analyses of the DUAL V 26-week trial. With IDegLira, mean HbA1c was reduced across all baseline HbA1c (1.0{\%}-2.5{\%}), FPG (1.5{\%}-1.9{\%}) and BMI categories (1.8{\%}-1.9{\%}), with significantly greater reductions compared with IGlar U100. For all HbA1c, FPG and BMI categories, IDegLira resulted in weight loss and IGlar U100 in weight gain; hypoglycaemia rates were lower for IDegLira vs IGlar U100. More patients achieved HbA1c <7{\%} with IDegLira than IGlar U100 across all HbA1c (59{\%}-87{\%} vs 31{\%}-66{\%}), FPG (71{\%}-74{\%} vs 40{\%}-51{\%}) and BMI categories (71{\%}-73{\%} vs 40{\%}-54{\%}). IDegLira improved glycaemic control and induced weight loss in patients with T2D previously uncontrolled on basal insulin, across the categories of baseline HbA1c, FPG or BMI that were tested.",
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