Insulin inhibits somatostatin-like immunoreactivity release stimulated by intragastric HCL

D. Rouiller, V. Schusdziarra, Roger H Unger

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

To determine the effect of an increase in insulin levels within the range occurring under physiologic conditions on the protein- and acid-induced release of splanchnic somatostatin, insulin was infused in dogs for 1 h following the intragastric instillation of a neutral protein load (20% liver extract at pH 7), a weak stimulus of somatostatin-like immunoreactivity (SLI), and after an intragastric HCI, a strong stimulus of SLI release, instilled 30 min later. Insulin levels between 50 and 60 μU/ml significantly reduced the rise in peripheral venous SLI levels elicited by the acid load from a mean integrated incremental value of 1705 ± 182 pg/ml in controls to 840 ± 312 in the insulin-infused group (P < 0.05). Prevention of the insulin-induced hypoglycemia and the secondary rise in glucagon, a known stimulus of pancreatic somatostatin secretion, by means of a concomitant infusion of glucose, did not modify the reduction in acid-induced increase in plasma SLI concentration associated with hyperinsulinemia. Insulin-glucose infusion significantly lowered the SLI in the pancreaticoduodenal vein, and in the gastroepiploic vein draining the antrum (P < 0.02; P < 0.05), but not in the short gastric veins draining the fundus of the stomach in response to the acid load. It is concluded that a physiologic elevation of insulin levels causes significantly reduced response of SLI to an intragastric acid load in dogs. This reduction is explained by a diminished increment of SLI in the venous effluent of the pancreas and the antrum.

Original languageEnglish (US)
Pages (from-to)735-738
Number of pages4
JournalDiabetes
Volume30
Issue number9
StatePublished - 1981

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Insulin
Acids
Veins
Somatostatin
Stomach
Dogs
Glucose
Liver Extracts
Viscera
Hyperinsulinism
somatostatin-like peptides
Glucagon
Hypoglycemia
Pancreas
Proteins

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Insulin inhibits somatostatin-like immunoreactivity release stimulated by intragastric HCL. / Rouiller, D.; Schusdziarra, V.; Unger, Roger H.

In: Diabetes, Vol. 30, No. 9, 1981, p. 735-738.

Research output: Contribution to journalArticle

Rouiller, D. ; Schusdziarra, V. ; Unger, Roger H. / Insulin inhibits somatostatin-like immunoreactivity release stimulated by intragastric HCL. In: Diabetes. 1981 ; Vol. 30, No. 9. pp. 735-738.
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