Insulin-like growth factor-I and breast cancer therapy

Yasir H. Ibrahim, Douglas Yee, Kent Osborne, Stephen Johnston, Carlos Arteaga, Richard Santen

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Targeting hormonal and growth factor signaling pathways has proven to be useful in the treatment of breast cancer. In vitro, animal, and epidemiologic evidence provide a rationale for the relevance of the insulin-like growth factor (IGF) system to breast cancer biology. The IGF system has been implicated in promoting mitogenic, metastatic, and antiapoptotic phenotypes in breast cancer. As a consequence of the ability of IGF to promote tamorigenesis, pharmacologic interventions targeting the IGF system are being devised. Such strategies include decreasing ligand production, ligand binding, or receptor activation. In this article, directed anti-IGF strategies and the possible clinical impact of using such therapies for treating breast cancer are discussed.

Original languageEnglish (US)
Pages (from-to)944s-950s
JournalClinical Cancer Research
Volume11
Issue number2 II
StatePublished - Jan 15 2005

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Ibrahim, Y. H., Yee, D., Osborne, K., Johnston, S., Arteaga, C., & Santen, R. (2005). Insulin-like growth factor-I and breast cancer therapy. Clinical Cancer Research, 11(2 II), 944s-950s.