Insulin Resistance - A Secret Killer?

Research output: Contribution to journalEditorial

83 Scopus citations

Abstract

In his Banting Lecture in 1988, Reaven coined the term “Syndrome X” to describe the following constellation: resistance to insulin-stimulated glucose uptake, glucose intolerance, hyperinsulinemia, increased levels of very-low-density lipoprotein (VLDL) triglyceride, decreased levels of high-density lipoprotein (HDL) cholesterol, and hypertension.1 The phenomenon of insulin resistance is well known in obesity, polycystic ovary syndrome, diabetes mellitus, lupus and other autoimmune diseases characterized by antibodies to the insulin receptor, partial or complete lipodystrophy, rare disorders such as leprechaunism, and a variety of endocrine diseases.2 It is generally considered to be secondary in these conditions, with a reversion to normal if the.

Original languageEnglish (US)
Pages (from-to)733-734
Number of pages2
JournalNew England Journal of Medicine
Volume320
Issue number11
DOIs
StatePublished - Mar 16 1989

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Insulin Resistance - A Secret Killer?'. Together they form a unique fingerprint.

Cite this