Insulin resistance in Hispanic large-for-gestational-age neonates at birth

Jennifer Shine Dyer, Charles R. Rosenfeld, Julie Rice, Mark Rice, Dana S. Hardin

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Content: Intrauterine exposure to maternal diabetes and large size at birth are known risk factors for the subsequent development of insulin resistance and metabolic syndrome. Although Hispanic youth have been shown to have a high prevalence of metabolic syndrome, it is unknown whether metabolic abnormalities and a predisposition for glucose intolerance are present at birth. Objective: The objective of the study was to determine whether abnormalities in insulin sensitivity exist at or soon after birth in large-for-gestational-age neonates born to Hispanic women with and without gestational diabetes. Design/Patients/Setting: Forty-two term Hispanic neonates were enrolled for cross-sectional studies at 24-48 h after birth and included nine large-for-gestational-age neonates delivered of women with gestational diabetes (large-for-gestational-age-IDM), 12 large-for-gestational-age but not IDM neonates, 11 poorly grown (at the fifth to 10th percentile), and 10 appropriate-for-gestational-age neonates. Insulin sensitivity and secretion were measured by shortened fasting iv glucose tolerance test. Main Outcome Measure: Insulin sensitivity index was measured within 48 h of birth. Results: Neonates were studied at 36 ± 11 h postnatally, and all groups were euglycemic at the time of study. However, insulin sensitivity was significantly lower (P < 0.05, ANOVA) in large-for-gestational-age-IDM [3.0 ± 0.7 (SEM) mU/liter·min] and large-for-gestational-age-non-IDM (2.2 ± 0.4 mU/liter·min) cohorts in comparison with poorly grown (5.0 ± 0.7 mU/liter·min) and appropriate-for-gestational-age controls (5.4 ± 0.8 mU/liter·min). Insulin secretion did not differ between groups. Conclusions: Reduced insulin sensitivity is present soon after birth in Hispanic large-for-gestational-age neonates born to mothers with and without gestational diabetes, demonstrating the onset of insulin resistance before birth and evidence of altered fetal programming.

Original languageEnglish (US)
Pages (from-to)3836-3843
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Volume92
Issue number10
DOIs
StatePublished - Oct 2007

Fingerprint

Hispanic Americans
Gestational Age
Insulin Resistance
Parturition
Newborn Infant
Insulin
Medical problems
Gestational Diabetes
Glucose
Maternal Exposure
Time and Motion Studies
Glucose Intolerance
Analysis of variance (ANOVA)
Glucose Tolerance Test
Fetal Development
Fasting
Analysis of Variance
Cross-Sectional Studies
Mothers
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Insulin resistance in Hispanic large-for-gestational-age neonates at birth. / Dyer, Jennifer Shine; Rosenfeld, Charles R.; Rice, Julie; Rice, Mark; Hardin, Dana S.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 92, No. 10, 10.2007, p. 3836-3843.

Research output: Contribution to journalArticle

Dyer, Jennifer Shine ; Rosenfeld, Charles R. ; Rice, Julie ; Rice, Mark ; Hardin, Dana S. / Insulin resistance in Hispanic large-for-gestational-age neonates at birth. In: Journal of Clinical Endocrinology and Metabolism. 2007 ; Vol. 92, No. 10. pp. 3836-3843.
@article{64e5bda1d9b24475b1c9134905b4c071,
title = "Insulin resistance in Hispanic large-for-gestational-age neonates at birth",
abstract = "Content: Intrauterine exposure to maternal diabetes and large size at birth are known risk factors for the subsequent development of insulin resistance and metabolic syndrome. Although Hispanic youth have been shown to have a high prevalence of metabolic syndrome, it is unknown whether metabolic abnormalities and a predisposition for glucose intolerance are present at birth. Objective: The objective of the study was to determine whether abnormalities in insulin sensitivity exist at or soon after birth in large-for-gestational-age neonates born to Hispanic women with and without gestational diabetes. Design/Patients/Setting: Forty-two term Hispanic neonates were enrolled for cross-sectional studies at 24-48 h after birth and included nine large-for-gestational-age neonates delivered of women with gestational diabetes (large-for-gestational-age-IDM), 12 large-for-gestational-age but not IDM neonates, 11 poorly grown (at the fifth to 10th percentile), and 10 appropriate-for-gestational-age neonates. Insulin sensitivity and secretion were measured by shortened fasting iv glucose tolerance test. Main Outcome Measure: Insulin sensitivity index was measured within 48 h of birth. Results: Neonates were studied at 36 ± 11 h postnatally, and all groups were euglycemic at the time of study. However, insulin sensitivity was significantly lower (P < 0.05, ANOVA) in large-for-gestational-age-IDM [3.0 ± 0.7 (SEM) mU/liter·min] and large-for-gestational-age-non-IDM (2.2 ± 0.4 mU/liter·min) cohorts in comparison with poorly grown (5.0 ± 0.7 mU/liter·min) and appropriate-for-gestational-age controls (5.4 ± 0.8 mU/liter·min). Insulin secretion did not differ between groups. Conclusions: Reduced insulin sensitivity is present soon after birth in Hispanic large-for-gestational-age neonates born to mothers with and without gestational diabetes, demonstrating the onset of insulin resistance before birth and evidence of altered fetal programming.",
author = "Dyer, {Jennifer Shine} and Rosenfeld, {Charles R.} and Julie Rice and Mark Rice and Hardin, {Dana S.}",
year = "2007",
month = "10",
doi = "10.1210/jc.2007-0079",
language = "English (US)",
volume = "92",
pages = "3836--3843",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "10",

}

TY - JOUR

T1 - Insulin resistance in Hispanic large-for-gestational-age neonates at birth

AU - Dyer, Jennifer Shine

AU - Rosenfeld, Charles R.

AU - Rice, Julie

AU - Rice, Mark

AU - Hardin, Dana S.

PY - 2007/10

Y1 - 2007/10

N2 - Content: Intrauterine exposure to maternal diabetes and large size at birth are known risk factors for the subsequent development of insulin resistance and metabolic syndrome. Although Hispanic youth have been shown to have a high prevalence of metabolic syndrome, it is unknown whether metabolic abnormalities and a predisposition for glucose intolerance are present at birth. Objective: The objective of the study was to determine whether abnormalities in insulin sensitivity exist at or soon after birth in large-for-gestational-age neonates born to Hispanic women with and without gestational diabetes. Design/Patients/Setting: Forty-two term Hispanic neonates were enrolled for cross-sectional studies at 24-48 h after birth and included nine large-for-gestational-age neonates delivered of women with gestational diabetes (large-for-gestational-age-IDM), 12 large-for-gestational-age but not IDM neonates, 11 poorly grown (at the fifth to 10th percentile), and 10 appropriate-for-gestational-age neonates. Insulin sensitivity and secretion were measured by shortened fasting iv glucose tolerance test. Main Outcome Measure: Insulin sensitivity index was measured within 48 h of birth. Results: Neonates were studied at 36 ± 11 h postnatally, and all groups were euglycemic at the time of study. However, insulin sensitivity was significantly lower (P < 0.05, ANOVA) in large-for-gestational-age-IDM [3.0 ± 0.7 (SEM) mU/liter·min] and large-for-gestational-age-non-IDM (2.2 ± 0.4 mU/liter·min) cohorts in comparison with poorly grown (5.0 ± 0.7 mU/liter·min) and appropriate-for-gestational-age controls (5.4 ± 0.8 mU/liter·min). Insulin secretion did not differ between groups. Conclusions: Reduced insulin sensitivity is present soon after birth in Hispanic large-for-gestational-age neonates born to mothers with and without gestational diabetes, demonstrating the onset of insulin resistance before birth and evidence of altered fetal programming.

AB - Content: Intrauterine exposure to maternal diabetes and large size at birth are known risk factors for the subsequent development of insulin resistance and metabolic syndrome. Although Hispanic youth have been shown to have a high prevalence of metabolic syndrome, it is unknown whether metabolic abnormalities and a predisposition for glucose intolerance are present at birth. Objective: The objective of the study was to determine whether abnormalities in insulin sensitivity exist at or soon after birth in large-for-gestational-age neonates born to Hispanic women with and without gestational diabetes. Design/Patients/Setting: Forty-two term Hispanic neonates were enrolled for cross-sectional studies at 24-48 h after birth and included nine large-for-gestational-age neonates delivered of women with gestational diabetes (large-for-gestational-age-IDM), 12 large-for-gestational-age but not IDM neonates, 11 poorly grown (at the fifth to 10th percentile), and 10 appropriate-for-gestational-age neonates. Insulin sensitivity and secretion were measured by shortened fasting iv glucose tolerance test. Main Outcome Measure: Insulin sensitivity index was measured within 48 h of birth. Results: Neonates were studied at 36 ± 11 h postnatally, and all groups were euglycemic at the time of study. However, insulin sensitivity was significantly lower (P < 0.05, ANOVA) in large-for-gestational-age-IDM [3.0 ± 0.7 (SEM) mU/liter·min] and large-for-gestational-age-non-IDM (2.2 ± 0.4 mU/liter·min) cohorts in comparison with poorly grown (5.0 ± 0.7 mU/liter·min) and appropriate-for-gestational-age controls (5.4 ± 0.8 mU/liter·min). Insulin secretion did not differ between groups. Conclusions: Reduced insulin sensitivity is present soon after birth in Hispanic large-for-gestational-age neonates born to mothers with and without gestational diabetes, demonstrating the onset of insulin resistance before birth and evidence of altered fetal programming.

UR - http://www.scopus.com/inward/record.url?scp=35349012140&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35349012140&partnerID=8YFLogxK

U2 - 10.1210/jc.2007-0079

DO - 10.1210/jc.2007-0079

M3 - Article

C2 - 17635945

AN - SCOPUS:35349012140

VL - 92

SP - 3836

EP - 3843

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 10

ER -