Insulin resitance and diabetes, mechanism and possible intervention

M. Koffler, L. C. Ramirez, Philip Raskin

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The issue of the peripheral resistance to insulin action has been getting a lot of attention over the last decade. The reason for this is that insulin is a major regulatory hormone and is involved in the metabolism of carbohydrates, lipids, protein and ions. To understand the pathophysiology of insulin resistance it is necessary to elucidate the methods for the assessment of insulin resistance and the molecular mechanism of insulin action. Insulin action is impaired in pathologic and physiologic states such as diabetes mellitus and obesity as well as in some rare syndromes. Further understanding of the pathophysiology of the impaired action of insulin improves the chances of defining new ways of treatment to improve the sensitivity to insulin action.

Original languageEnglish (US)
Pages (from-to)83-98
Number of pages16
JournalDiabetes Research and Clinical Practice
Volume7
Issue number2
DOIs
StatePublished - 1989

Fingerprint

Insulin
Insulin Resistance
Carbohydrate Metabolism
Lipid Metabolism
Vascular Resistance
Diabetes Mellitus
Obesity
Hormones
Ions
Proteins
Therapeutics

Keywords

  • Glucose clamp
  • Insulin
  • Insulin receptor
  • Insulin resistance
  • Phosphorylation
  • Protein kinase

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Insulin resitance and diabetes, mechanism and possible intervention. / Koffler, M.; Ramirez, L. C.; Raskin, Philip.

In: Diabetes Research and Clinical Practice, Vol. 7, No. 2, 1989, p. 83-98.

Research output: Contribution to journalArticle

@article{fb1d14e9cbce40bbb76a1dd3ae00f9a3,
title = "Insulin resitance and diabetes, mechanism and possible intervention",
abstract = "The issue of the peripheral resistance to insulin action has been getting a lot of attention over the last decade. The reason for this is that insulin is a major regulatory hormone and is involved in the metabolism of carbohydrates, lipids, protein and ions. To understand the pathophysiology of insulin resistance it is necessary to elucidate the methods for the assessment of insulin resistance and the molecular mechanism of insulin action. Insulin action is impaired in pathologic and physiologic states such as diabetes mellitus and obesity as well as in some rare syndromes. Further understanding of the pathophysiology of the impaired action of insulin improves the chances of defining new ways of treatment to improve the sensitivity to insulin action.",
keywords = "Glucose clamp, Insulin, Insulin receptor, Insulin resistance, Phosphorylation, Protein kinase",
author = "M. Koffler and Ramirez, {L. C.} and Philip Raskin",
year = "1989",
doi = "10.1016/0168-8227(89)90098-3",
language = "English (US)",
volume = "7",
pages = "83--98",
journal = "Diabetes Research and Clinical Practice",
issn = "0168-8227",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Insulin resitance and diabetes, mechanism and possible intervention

AU - Koffler, M.

AU - Ramirez, L. C.

AU - Raskin, Philip

PY - 1989

Y1 - 1989

N2 - The issue of the peripheral resistance to insulin action has been getting a lot of attention over the last decade. The reason for this is that insulin is a major regulatory hormone and is involved in the metabolism of carbohydrates, lipids, protein and ions. To understand the pathophysiology of insulin resistance it is necessary to elucidate the methods for the assessment of insulin resistance and the molecular mechanism of insulin action. Insulin action is impaired in pathologic and physiologic states such as diabetes mellitus and obesity as well as in some rare syndromes. Further understanding of the pathophysiology of the impaired action of insulin improves the chances of defining new ways of treatment to improve the sensitivity to insulin action.

AB - The issue of the peripheral resistance to insulin action has been getting a lot of attention over the last decade. The reason for this is that insulin is a major regulatory hormone and is involved in the metabolism of carbohydrates, lipids, protein and ions. To understand the pathophysiology of insulin resistance it is necessary to elucidate the methods for the assessment of insulin resistance and the molecular mechanism of insulin action. Insulin action is impaired in pathologic and physiologic states such as diabetes mellitus and obesity as well as in some rare syndromes. Further understanding of the pathophysiology of the impaired action of insulin improves the chances of defining new ways of treatment to improve the sensitivity to insulin action.

KW - Glucose clamp

KW - Insulin

KW - Insulin receptor

KW - Insulin resistance

KW - Phosphorylation

KW - Protein kinase

UR - http://www.scopus.com/inward/record.url?scp=0024454338&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024454338&partnerID=8YFLogxK

U2 - 10.1016/0168-8227(89)90098-3

DO - 10.1016/0168-8227(89)90098-3

M3 - Article

VL - 7

SP - 83

EP - 98

JO - Diabetes Research and Clinical Practice

JF - Diabetes Research and Clinical Practice

SN - 0168-8227

IS - 2

ER -