Insulin signaling in the nervous system regulates ethanol intoxication in Drosophila melanogaster

Ammon B. Corl; Aylin R. Rodan; Ulrike Heberlein

doi:10.1038/nn1363

Insulin signaling in the nervous system regulates ethanol intoxication in Drosophila melanogaster

Ammon B. Corl, Aylin R. Rodan, Ulrike Heberlein

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

The insulin signaling pathway regulates multiple physiological processes, including energy metabolism, organismal growth, aging and reproduction. Here we show that genetic manipulations in Drosophila melanogaster that impair the function of insulin-producing cells or of the insulin-receptor signaling pathway in the nervous system lead to increased sensitivity to the intoxicating effects of ethanol. These findings suggest a previously unknown role for this highly conserved pathway in regulating the behavioral responses to an addictive drug.

Original language	English (US)
Pages (from-to)	18-19
Number of pages	2
Journal	Nature neuroscience
Volume	8
Issue number	1
DOIs	https://doi.org/10.1038/nn1363
State	Published - Jan 2005

ASJC Scopus subject areas

General Neuroscience

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abstract = "The insulin signaling pathway regulates multiple physiological processes, including energy metabolism, organismal growth, aging and reproduction. Here we show that genetic manipulations in Drosophila melanogaster that impair the function of insulin-producing cells or of the insulin-receptor signaling pathway in the nervous system lead to increased sensitivity to the intoxicating effects of ethanol. These findings suggest a previously unknown role for this highly conserved pathway in regulating the behavioral responses to an addictive drug.",

author = "Corl, {Ammon B.} and Rodan, {Aylin R.} and Ulrike Heberlein",

note = "Funding Information: We thank E. Rulifson, M. J{\"u}nger and E. Hafen for providing fly strains prior to publication. This work was supported by US National Institutes of Health grants AA10035 and AA13105, and by the McKnight Foundation for Neuroscience.",

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Insulin signaling in the nervous system regulates ethanol intoxication in Drosophila melanogaster

Abstract

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