Insulin signaling in the nervous system regulates ethanol intoxication in Drosophila melanogaster

Ammon B. Corl, Aylin R. Rodan, Ulrike Heberlein

Research output: Contribution to journalArticle

68 Scopus citations


The insulin signaling pathway regulates multiple physiological processes, including energy metabolism, organismal growth, aging and reproduction. Here we show that genetic manipulations in Drosophila melanogaster that impair the function of insulin-producing cells or of the insulin-receptor signaling pathway in the nervous system lead to increased sensitivity to the intoxicating effects of ethanol. These findings suggest a previously unknown role for this highly conserved pathway in regulating the behavioral responses to an addictive drug.

Original languageEnglish (US)
Pages (from-to)18-19
Number of pages2
JournalNature Neuroscience
Issue number1
Publication statusPublished - Jan 2005


ASJC Scopus subject areas

  • Neuroscience(all)

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