Insulin therapy in obese, non-insulin-dependent diabetes induces improvements in insulin action and secretion that are maintained for two weeks after insulin withdrawal

W. J. Andrews, B. Vasquez, M. Nagulesparan, I. Klimes, J. Foley, Roger H Unger, G. M. Reaven

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Abstract

The effects of rigorous insulin treatment on insulin action (insulin clamp) and secretion (plasma insulin response to glucose) were studied in 13 obese patients with non-insulin-dependent diabetes mellitus (NIDDM). Improvements were documented in fasting (P <0.0001) and postprandial (P <0.0001) plasma glucose concentrations, insulin secretion after oral glucose (P <0.001), and insulin action (P <0.005) after 30 days of therapy. Mean integrated plasma insulin response to glucose increased 2.5-fold after insulin therapy, but this improvement varied considerably from patient to patient. Insulin action also increased with insulin treatment and the resulting values were no longer significantly different from a weight- and age-matched group of subjects with normal glucose tolerance. However, there was considerable patient-to-patient variation in the degree to which insulin action was enhanced. The insulin-induced improvements in glucose tolerance persisted for at least 2 wk after insulin withdrawal, and were associated with continued increased insulin secretion and insulin action. In conclusion, control of hyperglycemia for 1 mo led to improvements in both insulin secretion and action in a series of obese patients with NIDDM that persisted for at least 2 wk after cessation of therapy.

Original languageEnglish (US)
Pages (from-to)634-642
Number of pages9
JournalDiabetes
Volume33
Issue number7
StatePublished - 1984

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Insulin
Therapeutics
Glucose
Type 2 Diabetes Mellitus
Hyperglycemia
Fasting
Research Design
Age Groups
Weights and Measures

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Insulin therapy in obese, non-insulin-dependent diabetes induces improvements in insulin action and secretion that are maintained for two weeks after insulin withdrawal. / Andrews, W. J.; Vasquez, B.; Nagulesparan, M.; Klimes, I.; Foley, J.; Unger, Roger H; Reaven, G. M.

In: Diabetes, Vol. 33, No. 7, 1984, p. 634-642.

Research output: Contribution to journalArticle

Andrews, W. J. ; Vasquez, B. ; Nagulesparan, M. ; Klimes, I. ; Foley, J. ; Unger, Roger H ; Reaven, G. M. / Insulin therapy in obese, non-insulin-dependent diabetes induces improvements in insulin action and secretion that are maintained for two weeks after insulin withdrawal. In: Diabetes. 1984 ; Vol. 33, No. 7. pp. 634-642.
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