Integrated magnetic resonance imaging and phosphorus spectroscopy of soft tissue tumors

M. A. Shinkwin, R. E. Lenkinski, J. M. Daly, M. B. Zlatkin, T. S. Frank, G. A. Holland, H. Y. Kressel

Research output: Contribution to journalArticle

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Abstract

Eighteen patients with soft tissue masses underwent integrated magnetic resonance imaging (MRI) and phosphorus spectroscopy (31P-MRS) to evaluate benign and malignant tumor morphology and metabolism. Spectra from soft tissue tumors had a significantly higher proportion of phosphate in the low-energy portion of the 31P spectrum (P < 0.001) with a concomitant decrease in phosphocreatine (P < 0.01) compared with 31P spectra from normal muscle. Malignant tumors had a mean pH of 7.35 ± 0.13 which was greater than that of muscle tissue with a mean pH of 7.08 ± 0.07 (P < 0.001). All tumors had greater relative levels of phosphomonoesters, inorganic phosphate, and phosphodiesters compared with those in muscle tissue but considerable variability among tumors was noted due to tumor size, extent of tumor necrosis, and muscle contamination. Integrated MRI/MRS studies are necessary to provide exact localization of the tumor and a more correct interpretation of the 31P-MRS data.

Original languageEnglish (US)
Pages (from-to)1849-1858
Number of pages10
JournalCancer
Volume67
Issue number7
StatePublished - 1991

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Phosphorus
Spectrum Analysis
Magnetic Resonance Imaging
Neoplasms
Muscles
Phosphates
Phosphocreatine
Necrosis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Shinkwin, M. A., Lenkinski, R. E., Daly, J. M., Zlatkin, M. B., Frank, T. S., Holland, G. A., & Kressel, H. Y. (1991). Integrated magnetic resonance imaging and phosphorus spectroscopy of soft tissue tumors. Cancer, 67(7), 1849-1858.

Integrated magnetic resonance imaging and phosphorus spectroscopy of soft tissue tumors. / Shinkwin, M. A.; Lenkinski, R. E.; Daly, J. M.; Zlatkin, M. B.; Frank, T. S.; Holland, G. A.; Kressel, H. Y.

In: Cancer, Vol. 67, No. 7, 1991, p. 1849-1858.

Research output: Contribution to journalArticle

Shinkwin, MA, Lenkinski, RE, Daly, JM, Zlatkin, MB, Frank, TS, Holland, GA & Kressel, HY 1991, 'Integrated magnetic resonance imaging and phosphorus spectroscopy of soft tissue tumors', Cancer, vol. 67, no. 7, pp. 1849-1858.
Shinkwin MA, Lenkinski RE, Daly JM, Zlatkin MB, Frank TS, Holland GA et al. Integrated magnetic resonance imaging and phosphorus spectroscopy of soft tissue tumors. Cancer. 1991;67(7):1849-1858.
Shinkwin, M. A. ; Lenkinski, R. E. ; Daly, J. M. ; Zlatkin, M. B. ; Frank, T. S. ; Holland, G. A. ; Kressel, H. Y. / Integrated magnetic resonance imaging and phosphorus spectroscopy of soft tissue tumors. In: Cancer. 1991 ; Vol. 67, No. 7. pp. 1849-1858.
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