Integration of novel materials and advanced genomic technologies into new vaccine design

Wenzhen Liao, Tian Tian Zhang, Liqian Gao, Su Seong Lee, Jie Xu, Han Zhang, Zhaogang Yang, Zhaoyu Liu, Wen Li

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

Designing new vaccines is one of the most challenging tasks for public health to prevent both infectious and chronic diseases. Even though many research scientists have spent great efforts in improving the specificity, sensitivity and safety of current available vaccines, there are still much space on how to effectively combine different biomaterials and technologies to design universal or personalized vaccines. Traditionally, vaccines were made based on empirical approaches designed to mimic immunity induced by natural infection. Either live attenuated or killed whole microorganisms were used as vaccines. With the development of biomaterial science, DNA/RNA, recombinant vector, adjuvant and nanoparticles greatly expand the category of vaccines. More importantly, with the tremendous advances of new technologies including genomics, proteomics and immunomics, the paradigm of vaccine design has shifted from microbiological to sequence-based approaches. This ever-growing large amount of genomic data and new genomic approaches such as comparative genomics, reverse vaccinology and pan-genomics, will play critical roles in novel vaccine design and enable development of more effective vaccines to cure and control both chronic and infectious diseases. In this review, we summarize current various vaccine materials, advanced technologies and combinational strategies to integrate biomaterials and advanced technologies for vaccine design, which we hope will provide some very useful guidelines and perspectives for the vaccine design.

Original languageEnglish (US)
Pages (from-to)2286-2301
Number of pages16
JournalCurrent topics in medicinal chemistry
Volume17
Issue number20
DOIs
StatePublished - Aug 1 2017
Externally publishedYes

Keywords

  • Antigen
  • Genomics
  • Immune response
  • Reverse vaccinology
  • Vaccine

ASJC Scopus subject areas

  • Drug Discovery

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