Integration of Real-Time Internal Electromagnetic Position Monitoring Coupled With Dynamic Multileaf Collimator Tracking: An Intensity-Modulated Radiation Therapy Feasibility Study

Ryan L. Smith, Amit Sawant, Lakshmi Santanam, Raghu B. Venkat, Laurence J. Newell, Byung chul Cho, Per Poulsen, Herbert Catell, Paul J. Keall, Parag J. Parikh

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Purpose: Continuous tumor position measurement coupled with a tumor tracking system would result in a highly accurate radiation therapy system. Previous internal position monitoring systems have been limited by fluoroscopic radiation dose and low delivery efficiency. We aimed to incorporate a continuous, electromagnetic, three-dimensional position tracking system (Calypso 4D Localization System) with a dynamic multileaf collimator (DMLC)-based dose delivery system. Methods and Materials: A research version of the Calypso System provided real-time position of three Beacon transponders. These real-time three-dimensional positions were sent to research MLC controller with a motion-tracking algorithm that changed the planned leaf sequence. Electromagnetic transponders were embedded in a solid water film phantom that moved with patient lung trajectories while being irradiated with two different plans: a step-and-shoot intensity-modulated radiation therapy (S-IMRT) field and a dynamic IMRT (D-IMRT) field. Dosimetric results were recorded under three conditions: no intervention, DMLC tracking, and a spatial gating system. Results: Dosimetric accuracy was comparable for gating and DMLC tracking. Failure rates for gating/DMLC tracking are as follows: ±3 cGy 10.9/ 7.5% for S-IMRT, 3.3/7.2% for D-IMRT; gamma (3mm/3%) 0.2/1.2% for S-IMRT, 0.2/0.2% for D-IMRT. DMLC tracking proved to be as efficient as standard delivery, with a two- to fivefold efficiency increase over gating. Conclusions: Real-time target position information was successfully integrated into a DMLC effector system to modify dose delivery. Experimental results show both comparable dosimetric accuracy as well as improved efficiency compared with spatial gating.

Original languageEnglish (US)
Pages (from-to)868-875
Number of pages8
JournalInternational Journal of Radiation Oncology Biology Physics
Volume74
Issue number3
DOIs
StatePublished - Jul 1 2009

Fingerprint

Electromagnetic Phenomena
Feasibility Studies
collimators
radiation therapy
Radiotherapy
electromagnetism
delivery
Calypso
transponders
Computer Systems
Research
dosage
Neoplasms
tumors
Radiation
Lung
effectors
Water
beacons
lungs

Keywords

  • Cancer
  • DMLC
  • Intensity modulation
  • Lung
  • Radiation therapy
  • Tracking

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation
  • Cancer Research

Cite this

Integration of Real-Time Internal Electromagnetic Position Monitoring Coupled With Dynamic Multileaf Collimator Tracking : An Intensity-Modulated Radiation Therapy Feasibility Study. / Smith, Ryan L.; Sawant, Amit; Santanam, Lakshmi; Venkat, Raghu B.; Newell, Laurence J.; Cho, Byung chul; Poulsen, Per; Catell, Herbert; Keall, Paul J.; Parikh, Parag J.

In: International Journal of Radiation Oncology Biology Physics, Vol. 74, No. 3, 01.07.2009, p. 868-875.

Research output: Contribution to journalArticle

Smith, Ryan L. ; Sawant, Amit ; Santanam, Lakshmi ; Venkat, Raghu B. ; Newell, Laurence J. ; Cho, Byung chul ; Poulsen, Per ; Catell, Herbert ; Keall, Paul J. ; Parikh, Parag J. / Integration of Real-Time Internal Electromagnetic Position Monitoring Coupled With Dynamic Multileaf Collimator Tracking : An Intensity-Modulated Radiation Therapy Feasibility Study. In: International Journal of Radiation Oncology Biology Physics. 2009 ; Vol. 74, No. 3. pp. 868-875.
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abstract = "Purpose: Continuous tumor position measurement coupled with a tumor tracking system would result in a highly accurate radiation therapy system. Previous internal position monitoring systems have been limited by fluoroscopic radiation dose and low delivery efficiency. We aimed to incorporate a continuous, electromagnetic, three-dimensional position tracking system (Calypso 4D Localization System) with a dynamic multileaf collimator (DMLC)-based dose delivery system. Methods and Materials: A research version of the Calypso System provided real-time position of three Beacon transponders. These real-time three-dimensional positions were sent to research MLC controller with a motion-tracking algorithm that changed the planned leaf sequence. Electromagnetic transponders were embedded in a solid water film phantom that moved with patient lung trajectories while being irradiated with two different plans: a step-and-shoot intensity-modulated radiation therapy (S-IMRT) field and a dynamic IMRT (D-IMRT) field. Dosimetric results were recorded under three conditions: no intervention, DMLC tracking, and a spatial gating system. Results: Dosimetric accuracy was comparable for gating and DMLC tracking. Failure rates for gating/DMLC tracking are as follows: ±3 cGy 10.9/ 7.5{\%} for S-IMRT, 3.3/7.2{\%} for D-IMRT; gamma (3mm/3{\%}) 0.2/1.2{\%} for S-IMRT, 0.2/0.2{\%} for D-IMRT. DMLC tracking proved to be as efficient as standard delivery, with a two- to fivefold efficiency increase over gating. Conclusions: Real-time target position information was successfully integrated into a DMLC effector system to modify dose delivery. Experimental results show both comparable dosimetric accuracy as well as improved efficiency compared with spatial gating.",
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