Integrin αIIbβ3 induces the adhesion and activation of mast cells through interaction with fibrinogen

Toshihiko Oki, Jiro Kitaura, Koji Eto, Yang Lu, Mari Maeda-Yamamoto, Naoki Inagaki, Hiroichi Nagai, Yoshinori Yamanishi, Hideaki Nakajina, Hidetoshi Kumagai, Toshio Kitamura

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Integrin αIIb, a well-known marker of megakaryocyte- platelet lineage, has been recently recognized on hemopoietic progenitors. We now demonstrate that integrin αIIbβ3 is highly expressed on mouse and human mast cells including mouse bone marrow-derived mast cells, peritoneal mast cells, and human cord blood-derived mast cells, and that its binding to extracellular matrix proteins leads to enhancement of biological functions of mast cells in concert with various stimuli. With exposure to various stimuli, including cross-linking of FcεcRI and stem cell factor, mast cells adhered to extracellular matrix proteins such as fibrinogen and von Willebrand factor in an integrin αIIbβ3- dependent manner. In addition, the binding of mast cells to fibrinogen enhanced proliferation, cytokine production, and migration and induced uptake of soluble fibrinogen in response to stem cell factor stimulation, implicating integrin αIIbβ3 in a variety of mast cell functions. In conclusion, mouse and human mast cells express functional integrin αIIbβ3.

Original languageEnglish (US)
Pages (from-to)52-60
Number of pages9
JournalJournal of Immunology
Volume176
Issue number1
StatePublished - Jan 1 2006

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Mast Cells
Integrins
Cell Communication
Fibrinogen
Stem Cell Factor
Extracellular Matrix Proteins
Megakaryocytes
von Willebrand Factor
Fetal Blood
Blood Platelets
Bone Marrow
Cytokines

ASJC Scopus subject areas

  • Immunology

Cite this

Oki, T., Kitaura, J., Eto, K., Lu, Y., Maeda-Yamamoto, M., Inagaki, N., ... Kitamura, T. (2006). Integrin αIIbβ3 induces the adhesion and activation of mast cells through interaction with fibrinogen. Journal of Immunology, 176(1), 52-60.

Integrin αIIbβ3 induces the adhesion and activation of mast cells through interaction with fibrinogen. / Oki, Toshihiko; Kitaura, Jiro; Eto, Koji; Lu, Yang; Maeda-Yamamoto, Mari; Inagaki, Naoki; Nagai, Hiroichi; Yamanishi, Yoshinori; Nakajina, Hideaki; Kumagai, Hidetoshi; Kitamura, Toshio.

In: Journal of Immunology, Vol. 176, No. 1, 01.01.2006, p. 52-60.

Research output: Contribution to journalArticle

Oki, T, Kitaura, J, Eto, K, Lu, Y, Maeda-Yamamoto, M, Inagaki, N, Nagai, H, Yamanishi, Y, Nakajina, H, Kumagai, H & Kitamura, T 2006, 'Integrin αIIbβ3 induces the adhesion and activation of mast cells through interaction with fibrinogen', Journal of Immunology, vol. 176, no. 1, pp. 52-60.
Oki T, Kitaura J, Eto K, Lu Y, Maeda-Yamamoto M, Inagaki N et al. Integrin αIIbβ3 induces the adhesion and activation of mast cells through interaction with fibrinogen. Journal of Immunology. 2006 Jan 1;176(1):52-60.
Oki, Toshihiko ; Kitaura, Jiro ; Eto, Koji ; Lu, Yang ; Maeda-Yamamoto, Mari ; Inagaki, Naoki ; Nagai, Hiroichi ; Yamanishi, Yoshinori ; Nakajina, Hideaki ; Kumagai, Hidetoshi ; Kitamura, Toshio. / Integrin αIIbβ3 induces the adhesion and activation of mast cells through interaction with fibrinogen. In: Journal of Immunology. 2006 ; Vol. 176, No. 1. pp. 52-60.
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