TY - JOUR
T1 - Integrity of the Cerebral Blood-Flow Response to Hyperoxia After Cardiopulmonary Bypass
AU - Floyd, Thomas F.
AU - Ratcliffe, Sarah J.
AU - Detre, John A.
AU - Woo, Y. Joseph
AU - Acker, Michael A.
AU - Bavaria, Joseph E.
AU - Resh, Brooke F.
AU - Pochettino, Alberto A.
AU - Eckenhoff, Roderic A.
N1 - Funding Information:
Supported by a grant from the Society of Cardiovascular Anesthesiologists.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2007/4
Y1 - 2007/4
N2 - Objective: In this study, the hypothesis that cardiopulmonary bypass (CPB) alters the cerebral blood flow (CBF) vasoconstrictive response to hyperoxia was tested. Design: A prospective, observational study was conducted. Setting: The study was conducted at a single university hospital. Participants: Subjects were patients who presented for cardiac surgery with CPB. Interventions: CBF was measured before and after CPB in 12 subjects while breathing 21% O2 and 100% O2. CBF was measured by using continuous arterial spin labeling (CASL) perfusion magnetic resonance imaging. Arterial pO2 (mmHg), pCO2 (mmHg), hemoglobin (Hgb), and oxygen content (CaO2) were also measured. Measurements and Main Results: Mean age of the 12 subjects was 63 ± 16 years. Hgb decreased from 12.0 (±2.4) g/dL to 9.2 (±2.9) g/dL postoperatively (p = 0.008). CBF increased by 39%, from 37.2 (±10.8) mL/100 g/min to 49.2 (±14.3)mL/100 g/min postoperatively (p = 0.01). In response to the hyperoxic challenge CBF decreased by 8.0 (±7.1) mL/100 g/min (21%) preoperatively and by 9.4 (±6.4) mL/100 g/min (19%) postoperatively (p = 0.58). By using multiple regression, the contribution of CPB to the hyperoxic CBF response (ΔCBF) was evaluated, while controlling for other potentially important covariates known to influence CBF, including age, baseline CBF on 21% O2, and changes in arterial pO2, pCO2, and CaO2. CPB state was not found to be a significant covariate in controlling the CBF response to hyperoxia. Conclusions: CPB does not impair the CBF response to hyperoxia.
AB - Objective: In this study, the hypothesis that cardiopulmonary bypass (CPB) alters the cerebral blood flow (CBF) vasoconstrictive response to hyperoxia was tested. Design: A prospective, observational study was conducted. Setting: The study was conducted at a single university hospital. Participants: Subjects were patients who presented for cardiac surgery with CPB. Interventions: CBF was measured before and after CPB in 12 subjects while breathing 21% O2 and 100% O2. CBF was measured by using continuous arterial spin labeling (CASL) perfusion magnetic resonance imaging. Arterial pO2 (mmHg), pCO2 (mmHg), hemoglobin (Hgb), and oxygen content (CaO2) were also measured. Measurements and Main Results: Mean age of the 12 subjects was 63 ± 16 years. Hgb decreased from 12.0 (±2.4) g/dL to 9.2 (±2.9) g/dL postoperatively (p = 0.008). CBF increased by 39%, from 37.2 (±10.8) mL/100 g/min to 49.2 (±14.3)mL/100 g/min postoperatively (p = 0.01). In response to the hyperoxic challenge CBF decreased by 8.0 (±7.1) mL/100 g/min (21%) preoperatively and by 9.4 (±6.4) mL/100 g/min (19%) postoperatively (p = 0.58). By using multiple regression, the contribution of CPB to the hyperoxic CBF response (ΔCBF) was evaluated, while controlling for other potentially important covariates known to influence CBF, including age, baseline CBF on 21% O2, and changes in arterial pO2, pCO2, and CaO2. CPB state was not found to be a significant covariate in controlling the CBF response to hyperoxia. Conclusions: CPB does not impair the CBF response to hyperoxia.
KW - anemia
KW - brain
KW - cardiopulmonary bypass
KW - cerebrovascular circulation
KW - magnetic resonance imaging
KW - neurologic injury
KW - oxygen
KW - vasoconstriction
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U2 - 10.1053/j.jvca.2006.02.017
DO - 10.1053/j.jvca.2006.02.017
M3 - Article
C2 - 17418734
AN - SCOPUS:34047254868
SN - 1053-0770
VL - 21
SP - 212
EP - 217
JO - Journal of cardiothoracic and vascular anesthesia
JF - Journal of cardiothoracic and vascular anesthesia
IS - 2
ER -