Inter-method reproducibility of biexponential R2 MR relaxometry for estimation of liver iron concentration

Ali Pirasteh, Qing Yuan, Diego Hernando, Scott B. Reeder, Ivan Pedrosa, Takeshi Yokoo

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: To assess the reproducibility of biexponential R2-relaxometry MRI for estimation of liver iron concentration (LIC) between proprietary and nonproprietary analysis methods. Methods: This single-center retrospective study, approved by investigational review board and compliant with the Health Insurance Portability and Accountability Act, included 40 liver MRI exams in 38 subjects with suspected or known iron overload. From spin-echo images of the liver, acquired at 5 different echo times (TE=6-18 ms), biexponential R2 maps were calculated using 1 proprietary (FerriScan, Resonance Health Ltd., Claremont WA, Australia) and 3 nonproprietary (simulated annealing, nonlinear least squares, dictionary search) analysis methods. Each subject's average liver R2 value was converted to LIC using a previously validated calibration curve. Inter-method reproducibility for liver R2 and LIC were assessed for linearity using linear regression analysis and absolute agreement using intraclass correlation and Bland-Altman analysis. For point estimates, 95% confidence intervals were calculated; P values<0.05 were considered statistically significant. Results: Linearity between the proprietary and nonproprietary methods was excellent across the observed range for R2 (20-312 s-1) and LIC (0.4-52.2mg/g), with all coefficients of determination (R2)≥0.95. No statistically significant bias was found (slope estimates ∼ 1; intercept estimates ∼ 0; P values>0.05). Agreement between the 4 methods was excellent for both liver R2 and LIC (intraclass correlations≥0.97). Bland-Altman 95% limits of agreement in % difference between the proprietary and nonproprietary methods were≤9% and≤16% for R2 and LIC, respectively. Conclusion: Biexponential R2-relaxometry MRI for LIC estimation is reproducible between proprietary and nonproprietary analysis methods.

Original languageEnglish (US)
JournalMagnetic Resonance in Medicine
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Iron
Liver
Health Insurance Portability and Accountability Act
Iron Overload
Least-Squares Analysis
Calibration
Linear Models
Retrospective Studies
Regression Analysis
Confidence Intervals
Health

Keywords

  • Hemochromatosis
  • Hemosiderosis
  • Iron overload
  • Liver iron concentration
  • R relaxation
  • Reproducibility
  • T relaxation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Inter-method reproducibility of biexponential R2 MR relaxometry for estimation of liver iron concentration. / Pirasteh, Ali; Yuan, Qing; Hernando, Diego; Reeder, Scott B.; Pedrosa, Ivan; Yokoo, Takeshi.

In: Magnetic Resonance in Medicine, 01.01.2018.

Research output: Contribution to journalArticle

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abstract = "Purpose: To assess the reproducibility of biexponential R2-relaxometry MRI for estimation of liver iron concentration (LIC) between proprietary and nonproprietary analysis methods. Methods: This single-center retrospective study, approved by investigational review board and compliant with the Health Insurance Portability and Accountability Act, included 40 liver MRI exams in 38 subjects with suspected or known iron overload. From spin-echo images of the liver, acquired at 5 different echo times (TE=6-18 ms), biexponential R2 maps were calculated using 1 proprietary (FerriScan, Resonance Health Ltd., Claremont WA, Australia) and 3 nonproprietary (simulated annealing, nonlinear least squares, dictionary search) analysis methods. Each subject's average liver R2 value was converted to LIC using a previously validated calibration curve. Inter-method reproducibility for liver R2 and LIC were assessed for linearity using linear regression analysis and absolute agreement using intraclass correlation and Bland-Altman analysis. For point estimates, 95{\%} confidence intervals were calculated; P values<0.05 were considered statistically significant. Results: Linearity between the proprietary and nonproprietary methods was excellent across the observed range for R2 (20-312 s-1) and LIC (0.4-52.2mg/g), with all coefficients of determination (R2)≥0.95. No statistically significant bias was found (slope estimates ∼ 1; intercept estimates ∼ 0; P values>0.05). Agreement between the 4 methods was excellent for both liver R2 and LIC (intraclass correlations≥0.97). Bland-Altman 95{\%} limits of agreement in {\%} difference between the proprietary and nonproprietary methods were≤9{\%} and≤16{\%} for R2 and LIC, respectively. Conclusion: Biexponential R2-relaxometry MRI for LIC estimation is reproducible between proprietary and nonproprietary analysis methods.",
keywords = "Hemochromatosis, Hemosiderosis, Iron overload, Liver iron concentration, R relaxation, Reproducibility, T relaxation",
author = "Ali Pirasteh and Qing Yuan and Diego Hernando and Reeder, {Scott B.} and Ivan Pedrosa and Takeshi Yokoo",
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AU - Pirasteh, Ali

AU - Yuan, Qing

AU - Hernando, Diego

AU - Reeder, Scott B.

AU - Pedrosa, Ivan

AU - Yokoo, Takeshi

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N2 - Purpose: To assess the reproducibility of biexponential R2-relaxometry MRI for estimation of liver iron concentration (LIC) between proprietary and nonproprietary analysis methods. Methods: This single-center retrospective study, approved by investigational review board and compliant with the Health Insurance Portability and Accountability Act, included 40 liver MRI exams in 38 subjects with suspected or known iron overload. From spin-echo images of the liver, acquired at 5 different echo times (TE=6-18 ms), biexponential R2 maps were calculated using 1 proprietary (FerriScan, Resonance Health Ltd., Claremont WA, Australia) and 3 nonproprietary (simulated annealing, nonlinear least squares, dictionary search) analysis methods. Each subject's average liver R2 value was converted to LIC using a previously validated calibration curve. Inter-method reproducibility for liver R2 and LIC were assessed for linearity using linear regression analysis and absolute agreement using intraclass correlation and Bland-Altman analysis. For point estimates, 95% confidence intervals were calculated; P values<0.05 were considered statistically significant. Results: Linearity between the proprietary and nonproprietary methods was excellent across the observed range for R2 (20-312 s-1) and LIC (0.4-52.2mg/g), with all coefficients of determination (R2)≥0.95. No statistically significant bias was found (slope estimates ∼ 1; intercept estimates ∼ 0; P values>0.05). Agreement between the 4 methods was excellent for both liver R2 and LIC (intraclass correlations≥0.97). Bland-Altman 95% limits of agreement in % difference between the proprietary and nonproprietary methods were≤9% and≤16% for R2 and LIC, respectively. Conclusion: Biexponential R2-relaxometry MRI for LIC estimation is reproducible between proprietary and nonproprietary analysis methods.

AB - Purpose: To assess the reproducibility of biexponential R2-relaxometry MRI for estimation of liver iron concentration (LIC) between proprietary and nonproprietary analysis methods. Methods: This single-center retrospective study, approved by investigational review board and compliant with the Health Insurance Portability and Accountability Act, included 40 liver MRI exams in 38 subjects with suspected or known iron overload. From spin-echo images of the liver, acquired at 5 different echo times (TE=6-18 ms), biexponential R2 maps were calculated using 1 proprietary (FerriScan, Resonance Health Ltd., Claremont WA, Australia) and 3 nonproprietary (simulated annealing, nonlinear least squares, dictionary search) analysis methods. Each subject's average liver R2 value was converted to LIC using a previously validated calibration curve. Inter-method reproducibility for liver R2 and LIC were assessed for linearity using linear regression analysis and absolute agreement using intraclass correlation and Bland-Altman analysis. For point estimates, 95% confidence intervals were calculated; P values<0.05 were considered statistically significant. Results: Linearity between the proprietary and nonproprietary methods was excellent across the observed range for R2 (20-312 s-1) and LIC (0.4-52.2mg/g), with all coefficients of determination (R2)≥0.95. No statistically significant bias was found (slope estimates ∼ 1; intercept estimates ∼ 0; P values>0.05). Agreement between the 4 methods was excellent for both liver R2 and LIC (intraclass correlations≥0.97). Bland-Altman 95% limits of agreement in % difference between the proprietary and nonproprietary methods were≤9% and≤16% for R2 and LIC, respectively. Conclusion: Biexponential R2-relaxometry MRI for LIC estimation is reproducible between proprietary and nonproprietary analysis methods.

KW - Hemochromatosis

KW - Hemosiderosis

KW - Iron overload

KW - Liver iron concentration

KW - R relaxation

KW - Reproducibility

KW - T relaxation

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