TY - JOUR
T1 - Inter-organelle ER-endolysosomal contact sites in metabolism and disease across evolution
AU - Hariri, Hanaa
AU - Ugrankar, Rupali
AU - Liu, Yang
AU - Henne, W. Mike
N1 - Publisher Copyright:
© 2016 The Author(s). Published with license by Taylor & Francis Group, LLC, Hanaa Hariri, Rupali Ugrankar, Yang Liu, and W. Mike Henne.
PY - 2016/5/3
Y1 - 2016/5/3
N2 - Since their initial observation, contact sites formed between different organelles have transitioned from ignored curiosities to recognized centers for the exchange of metabolites and lipids. Contact formed between the ER and endomembrane system (eg. the plasma membrane, endosomes, and lysosomes) is of particular biomedical interest, as it governs aspects of lipid metabolism, organelle identity, and cell signaling. Here, we review the field of ER-endolysosomal communication from the perspective of three model systems: budding yeast, the fruit fly D. melanogaster, and mammals. From this broad perspective, inter-organelle communication displays a consistent role in metabolic regulation that was differentially tuned during the development of complex metazoan life. We also examine the current state of understanding of lipid exchange between organelles, and discuss molecular mechanisms by which this occurs.
AB - Since their initial observation, contact sites formed between different organelles have transitioned from ignored curiosities to recognized centers for the exchange of metabolites and lipids. Contact formed between the ER and endomembrane system (eg. the plasma membrane, endosomes, and lysosomes) is of particular biomedical interest, as it governs aspects of lipid metabolism, organelle identity, and cell signaling. Here, we review the field of ER-endolysosomal communication from the perspective of three model systems: budding yeast, the fruit fly D. melanogaster, and mammals. From this broad perspective, inter-organelle communication displays a consistent role in metabolic regulation that was differentially tuned during the development of complex metazoan life. We also examine the current state of understanding of lipid exchange between organelles, and discuss molecular mechanisms by which this occurs.
KW - Endoplasmic reticulum (ER)
KW - inter-organelle communication
KW - membrane contact sites (MCSs)
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U2 - 10.1080/19420889.2016.1156278
DO - 10.1080/19420889.2016.1156278
M3 - Review article
C2 - 27489577
AN - SCOPUS:84976439935
SN - 1942-0889
VL - 9
JO - Communicative and Integrative Biology
JF - Communicative and Integrative Biology
IS - 3
ER -