Inter-organelle ER-endolysosomal contact sites in metabolism and disease across evolution

Hanaa Hariri, Rupali Ugrankar, Yang Liu, W. Mike Henne

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Since their initial observation, contact sites formed between different organelles have transitioned from ignored curiosities to recognized centers for the exchange of metabolites and lipids. Contact formed between the ER and endomembrane system (eg. the plasma membrane, endosomes, and lysosomes) is of particular biomedical interest, as it governs aspects of lipid metabolism, organelle identity, and cell signaling. Here, we review the field of ER-endolysosomal communication from the perspective of three model systems: budding yeast, the fruit fly D. melanogaster, and mammals. From this broad perspective, inter-organelle communication displays a consistent role in metabolic regulation that was differentially tuned during the development of complex metazoan life. We also examine the current state of understanding of lipid exchange between organelles, and discuss molecular mechanisms by which this occurs.

Original languageEnglish (US)
JournalCommunicative and Integrative Biology
Volume9
Issue number3
DOIs
StatePublished - May 3 2016

Fingerprint

Organelles
organelles
metabolism
animal communication
Communication
endomembrane system
Lipids
Melanogaster
Saccharomycetales
endosomes
Endosomes
lysosomes
lipids
fruit flies
Lysosomes
Lipid Metabolism
Diptera
lipid metabolism
Mammals
Fruit

Keywords

  • Endoplasmic reticulum (ER)
  • inter-organelle communication
  • membrane contact sites (MCSs)

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Inter-organelle ER-endolysosomal contact sites in metabolism and disease across evolution. / Hariri, Hanaa; Ugrankar, Rupali; Liu, Yang; Henne, W. Mike.

In: Communicative and Integrative Biology, Vol. 9, No. 3, 03.05.2016.

Research output: Contribution to journalReview article

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