Interaction between altered insulin and lipid metabolism in CEACAM1-inactive transgenic mice

Tong Dai, George A. Abou-Rjaily, Qusai Y. Al-Share', Yan Yang, Mats A. Fernström, Anthony M. DeAngelis, Abraham D. Lee, Lawrence Sweetman, Antonino Amato, Marzia Pasquali, Gary D. Lopaschuk, Sandra K. Erickson, Sonia M. Najjart

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Inactivation of CEACAM1 in L-SACC1 mice by a dominant-negative transgene in liver impairs insulin clearance and increases serum free fatty acid (FFA) levels, resulting in insulin resistance. The contribution of elevated FFAs in the pathogenesis of insulin resistance is herein investigated. Treatment of L-SACC1 female mice with carnitine restored plasma FFA content. Concomitantly, it normalized insulin levels without directly regulating receptor-mediated insulin internalization and prevented glucose tolerance in these mice. Similarly, treatment with nicotinic acid, a lipolysis inhibitor, restored insulin-stimulated receptor uptake in L-SACC1 mice. Taken together, these data suggest that chronic elevation in plasma FFAs levels contributes to the regulation of insulin metabolism and action in L-SACC1 mice.

Original languageEnglish (US)
Pages (from-to)45155-45161
Number of pages7
JournalJournal of Biological Chemistry
Volume279
Issue number43
DOIs
StatePublished - Oct 22 2004
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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