Interaction between Orexin Neurons and Monoaminergic Systems

Takeshi Sakurai, Yuki C. Saito, Masashi Yanagisawa

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Orexins have received a lot of attention as potent endogenous arousal-promoting peptides, and orexin receptor antagonists have shown clinical efficacy for the treatment of insomnia. Orexin neurons are thought to act primarily on monoaminergic neurons to maintain arousal and vigilance. In this chapter, we discuss the functional interaction between monoaminergic systems, including noradrenaline, serotonin and histamine, and orexin neurons, as well as interactions between the acetylcholine system and the orexin neurons, focusing, in particular, on their function in the regulation of sleep-wakefulness states. Orexin also has close interactions with the dopaminergic system, and many studies have suggested roles of orexin signaling in the reward system and roles for orexins in drug addiction.

Original languageEnglish (US)
Pages (from-to)11-21
Number of pages11
JournalFrontiers of Neurology and Neuroscience
StatePublished - 2021
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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