TY - JOUR
T1 - Interaction between Orexin Neurons and Monoaminergic Systems
AU - Sakurai, Takeshi
AU - Saito, Yuki C.
AU - Yanagisawa, Masashi
N1 - Funding Information:
This work was supported by a JSPS KAKENHI Grant-in-Aid for Scientific Research (B) (JP 18H02595) and a KAKENHI Grant-in-Aid for Scientific Research on Innovative Areas, “Will-dynamics” (16H06401).
Publisher Copyright:
© 2021 The Author(s).
PY - 2021
Y1 - 2021
N2 - Orexins have received a lot of attention as potent endogenous arousal-promoting peptides, and orexin receptor antagonists have shown clinical efficacy for the treatment of insomnia. Orexin neurons are thought to act primarily on monoaminergic neurons to maintain arousal and vigilance. In this chapter, we discuss the functional interaction between monoaminergic systems, including noradrenaline, serotonin and histamine, and orexin neurons, as well as interactions between the acetylcholine system and the orexin neurons, focusing, in particular, on their function in the regulation of sleep-wakefulness states. Orexin also has close interactions with the dopaminergic system, and many studies have suggested roles of orexin signaling in the reward system and roles for orexins in drug addiction.
AB - Orexins have received a lot of attention as potent endogenous arousal-promoting peptides, and orexin receptor antagonists have shown clinical efficacy for the treatment of insomnia. Orexin neurons are thought to act primarily on monoaminergic neurons to maintain arousal and vigilance. In this chapter, we discuss the functional interaction between monoaminergic systems, including noradrenaline, serotonin and histamine, and orexin neurons, as well as interactions between the acetylcholine system and the orexin neurons, focusing, in particular, on their function in the regulation of sleep-wakefulness states. Orexin also has close interactions with the dopaminergic system, and many studies have suggested roles of orexin signaling in the reward system and roles for orexins in drug addiction.
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U2 - 10.1159/000514955
DO - 10.1159/000514955
M3 - Article
C2 - 34052806
AN - SCOPUS:85107248753
VL - 45
SP - 11
EP - 21
JO - Frontiers of Neurology and Neuroscience
JF - Frontiers of Neurology and Neuroscience
SN - 1660-4431
ER -