Interaction of 16β-hydroxydehydroepiandrosterone with renal mineralocorticoid receptors

John R. Higgins, Gerhard Wambach, David C. Kem, Celso Gomez-Sanchez, O. Bryan Holland, Norman M Kaplan

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

A previously unidentified mineralocorticoid, 16β-hydroxydehydroepiandrosterone (16β OH-DHEA) has recently been isolated from urine extracts of patients with low-renin hypertension and reported to possess one-fortieth the mineralocorticoid potency of aldosterone by bioassay. However, using a radioreceptor assay, we demonstrate the affinity of 16β-OH-DHEA for renal 3H-aldosterone receptors to be only 0.011 per cent that of unlabeled aldosterone. 16β-OH-DHEA therefore would not be expected to possess significant mineralocorticoid properties unless its mechanism of action involves binding to a unique class of renal receptors. Until these discrepancies between bioassayable mineralocorticoid activity and affinity for mineralocorticoid receptors can be resolved, the role of 16β-OH-DHEA in the pathogenesis of low-renin hypertension remains speculative.

Original languageEnglish (US)
Pages (from-to)250-256
Number of pages7
JournalThe Journal of Laboratory and Clinical Medicine
Volume89
Issue number2
StatePublished - Feb 1977

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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