Interaction of Blood Manganese Concentrations with GSTT1 in Relation to Autism Spectrum Disorder in Jamaican Children

Mohammad H. Rahbar, Maureen Samms-Vaughan, Sepideh Saroukhani, Min Jae Lee, Jing Zhang, Jan Bressler, Manouchehr Hessabi, Sydonnie Shakespeare-Pellington, Megan L. Grove, Katherine A. Loveland

Research output: Contribution to journalArticle

Abstract

Using data from 266 age- and sex-matched pairs of Jamaican children with autism spectrum disorder (ASD) and typically developing (TD) controls (2–8 years), we investigated whether glutathione S-transferase theta 1 (GSTT1) modifies the association between blood manganese concentrations (BMC) and ASD. After adjusting conditional logistic regression models for socioeconomic status and the interaction between GSTT1 and GSTP1 (glutathione S-transferase pi 1), using a recessive genetic model for GSTT1 and either a co-dominant or dominant model for GSTP1, the interaction between GSTT1 and BMC was significant (P = 0.02, P = 0.01, respectively). Compared to controls, ASD cases with GSTT1-DD genotype had 4.33 and 4.34 times higher odds of BMC > 12 vs. ≤ 8.3 μg/L, respectively. Replication in other populations is warranted.

Original languageEnglish (US)
JournalJournal of Autism and Developmental Disorders
DOIs
StateAccepted/In press - 2020

Keywords

  • Autism spectrum disorder (ASD)
  • Blood manganese concentrations (BMC)
  • Conditional logistic regression (CLR)
  • Glutathione S-transferase (GST) genes
  • Interaction
  • Jamaica

ASJC Scopus subject areas

  • Developmental and Educational Psychology

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    Rahbar, M. H., Samms-Vaughan, M., Saroukhani, S., Lee, M. J., Zhang, J., Bressler, J., Hessabi, M., Shakespeare-Pellington, S., Grove, M. L., & Loveland, K. A. (Accepted/In press). Interaction of Blood Manganese Concentrations with GSTT1 in Relation to Autism Spectrum Disorder in Jamaican Children. Journal of Autism and Developmental Disorders. https://doi.org/10.1007/s10803-020-04677-z