TY - JOUR
T1 - Interaction of Blood Manganese Concentrations with GSTT1 in Relation to Autism Spectrum Disorder in Jamaican Children
AU - Rahbar, Mohammad H.
AU - Samms-Vaughan, Maureen
AU - Saroukhani, Sepideh
AU - Lee, Min Jae
AU - Zhang, Jing
AU - Bressler, Jan
AU - Hessabi, Manouchehr
AU - Shakespeare-Pellington, Sydonnie
AU - Grove, Megan L.
AU - Loveland, Katherine A.
N1 - Funding Information:
This research is funded by the National Institute of Environmental Health Sciences (NIEHS) by a grant (R01ES022165), as well as the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and the National Institutes of Health Fogarty International Center (NIH-FIC) by a grant (R21HD057808) awarded to University of Texas Health Science Center at Houston. We also acknowledge the support provided by the Biostatistics/Epidemiology/Research Design (BERD) component of the Center for Clinical and Translational Sciences (CCTS) for this project. CCTS is mainly funded by the NIH Centers for Translational Science Award (NIH CTSA) grant (UL1 RR024148), awarded to University of Texas Health Science Center at Houston in 2006 by the National Center for Research Resources (NCRR), and its 2012 renewal (UL1 TR000371) as well as another 2019 grant (UL1 TR003167) by the National Center for Advancing Translational Sciences (NCATS). Furthermore, we acknowledge that the collection and management of survey data were done using REDCap (Harris et al. ). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NICHD, NIH-FIC, NIEHS, NCRR, or NCATS. Finally, we acknowledge contributions by colleagues in the Analytical Chemistry Lab at MDHHS for analyzing and storing the whole blood samples for the assessments of Mn concentrations, under a service contract.
Funding Information:
This research is funded by the National Institute of Environmental Health Sciences (NIEHS) by a grant (R01ES022165), as well as the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and the National Institutes of Health Fogarty International Center (NIH-FIC) by a grant (R21HD057808) awarded to University of Texas Health Science Center at Houston. We also acknowledge the support provided by the Biostatistics/Epidemiology/Research Design (BERD) component of the Center for Clinical and Translational Sciences (CCTS) for this project. CCTS is mainly funded by the NIH Centers for Translational Science Award (NIH CTSA) grant (UL1 RR024148), awarded to University of Texas Health Science Center at Houston in 2006 by the National Center for Research Resources (NCRR), and its 2012 renewal (UL1 TR000371) as well as another 2019 grant (UL1?TR003167) by the National Center for Advancing Translational Sciences (NCATS). Furthermore, we acknowledge that the collection and management of survey data were done using REDCap (Harris et al. 2009). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NICHD, NIH-FIC, NIEHS, NCRR, or NCATS. Finally, we acknowledge contributions by colleagues in the Analytical Chemistry Lab at MDHHS for analyzing and storing the whole blood samples for the assessments of Mn concentrations, under a service contract.
Publisher Copyright:
© 2020, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2021/6
Y1 - 2021/6
N2 - Using data from 266 age- and sex-matched pairs of Jamaican children with autism spectrum disorder (ASD) and typically developing (TD) controls (2–8 years), we investigated whether glutathione S-transferase theta 1 (GSTT1) modifies the association between blood manganese concentrations (BMC) and ASD. After adjusting conditional logistic regression models for socioeconomic status and the interaction between GSTT1 and GSTP1 (glutathione S-transferase pi 1), using a recessive genetic model for GSTT1 and either a co-dominant or dominant model for GSTP1, the interaction between GSTT1 and BMC was significant (P = 0.02, P = 0.01, respectively). Compared to controls, ASD cases with GSTT1-DD genotype had 4.33 and 4.34 times higher odds of BMC > 12 vs. ≤ 8.3 μg/L, respectively. Replication in other populations is warranted.
AB - Using data from 266 age- and sex-matched pairs of Jamaican children with autism spectrum disorder (ASD) and typically developing (TD) controls (2–8 years), we investigated whether glutathione S-transferase theta 1 (GSTT1) modifies the association between blood manganese concentrations (BMC) and ASD. After adjusting conditional logistic regression models for socioeconomic status and the interaction between GSTT1 and GSTP1 (glutathione S-transferase pi 1), using a recessive genetic model for GSTT1 and either a co-dominant or dominant model for GSTP1, the interaction between GSTT1 and BMC was significant (P = 0.02, P = 0.01, respectively). Compared to controls, ASD cases with GSTT1-DD genotype had 4.33 and 4.34 times higher odds of BMC > 12 vs. ≤ 8.3 μg/L, respectively. Replication in other populations is warranted.
KW - Autism spectrum disorder (ASD)
KW - Blood manganese concentrations (BMC)
KW - Conditional logistic regression (CLR)
KW - Glutathione S-transferase (GST) genes
KW - Interaction
KW - Jamaica
UR - http://www.scopus.com/inward/record.url?scp=85090299914&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85090299914&partnerID=8YFLogxK
U2 - 10.1007/s10803-020-04677-z
DO - 10.1007/s10803-020-04677-z
M3 - Article
C2 - 32892263
AN - SCOPUS:85090299914
SN - 0162-3257
VL - 51
SP - 1953
EP - 1965
JO - Journal of Autism and Developmental Disorders
JF - Journal of Autism and Developmental Disorders
IS - 6
ER -