Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine-kinase receptor

Helmut Krämer, Ross L. Cagan, S. Lawrence Zipursky

Research output: Contribution to journalArticle

223 Citations (Scopus)

Abstract

During development of the Drosophila retina, the R8 photoreceptor neuron induces a neighbouring cell to assume an R7 cell fate. Genetic data suggest that the induction is mediated by two transmembrane proteins encoded by bride of sevenless and sevenless. A direct interaction between these two proteins was demonstrated by the heterotypic aggregation of cell lines expressing them. In the developing eye the sevenless-dependent internalization of bride of sevenless by the R7 precursor cell provides evidence for a direct interaction between these two proteins in vivo.

Original languageEnglish (US)
Pages (from-to)207-212
Number of pages6
JournalNature
Volume352
Issue number6332
StatePublished - Jul 18 1991

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Receptor Protein-Tyrosine Kinases
Ligands
Membranes
Proteins
Drosophila
Retina
Neurons
Cell Line

ASJC Scopus subject areas

  • General

Cite this

Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine-kinase receptor. / Krämer, Helmut; Cagan, Ross L.; Zipursky, S. Lawrence.

In: Nature, Vol. 352, No. 6332, 18.07.1991, p. 207-212.

Research output: Contribution to journalArticle

Krämer, Helmut ; Cagan, Ross L. ; Zipursky, S. Lawrence. / Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine-kinase receptor. In: Nature. 1991 ; Vol. 352, No. 6332. pp. 207-212.
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