Abstract
During development of the Drosophila retina, the R8 photoreceptor neuron induces a neighbouring cell to assume an R7 cell fate. Genetic data suggest that the induction is mediated by two transmem-brane proteins encoded by bride of sevenless and sevenless. A direct interaction between these two proteins was demonstrated by the heterotypic aggregation of cell lines expressing them. In the developing eye the sevenless-dependent internalization of bride of sevenless by the R7 precursor cell provides evidence for a direct interaction between these two proteins in vivo.
Original language | English (US) |
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Pages (from-to) | 207-212 |
Number of pages | 6 |
Journal | Nature |
Volume | 352 |
Issue number | 6332 |
DOIs | |
State | Published - 1991 |
ASJC Scopus subject areas
- General