Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine-kinase receptor

Helmut Krämer, Ross L. Cagan, S. Lawrence Zipursky

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Abstract

During development of the Drosophila retina, the R8 photoreceptor neuron induces a neighbouring cell to assume an R7 cell fate. Genetic data suggest that the induction is mediated by two transmembrane proteins encoded by bride of sevenless and sevenless. A direct interaction between these two proteins was demonstrated by the heterotypic aggregation of cell lines expressing them. In the developing eye the sevenless-dependent internalization of bride of sevenless by the R7 precursor cell provides evidence for a direct interaction between these two proteins in vivo.

Original languageEnglish (US)
Pages (from-to)207-212
Number of pages6
JournalNature
Volume352
Issue number6332
Publication statusPublished - Jul 18 1991

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