Interaction of C 60 fullerene with the proteins involved in DNA mismatch repair pathway

Shishir Kumar Gupta, Lokesh Baweja, Deepak Gurbani, Alok K. Pandey, Alok Dhawan

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Fullerenes are fascinating symmetric carbon nanostructures with a potential to bind DNA and proteins. Computational studies were performed to investigate the interaction of fullerenes with the proteins involved in DNA mismatch repair (MMR) pathway. Significant interactions of fullerene with PMS2, RFC3 and PCNA proteins were observed. These findings suggested that fullerene interferes in the human MMR process hence the subsequent disturbance may confer a large increase in spontaneous mutability and a strong predisposition to tumor development.

Original languageEnglish (US)
Pages (from-to)179-180
Number of pages2
JournalJournal of biomedical nanotechnology
Volume7
Issue number1
DOIs
StatePublished - Jan 1 2011
Externally publishedYes

Keywords

  • DNA mismatch repair
  • Docking
  • Fullerene
  • Homology modeling

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

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