Interaction of mature CD3+CD4+ T cells with dendritic cells triggers the development of tertiary lymphoid structures in the thyroid

Tatjana Marinkovic, Alexandre Garin, Yoshifumi Yokota, Yang Xin Fu, Nancy H. Ruddle, Glaucia C. Furtado, Sergio A. Lira

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Ectopic expression of CC chemokine ligand 21 (CCL21) in the thyroid leads to development of lymphoid structures that resemble those observed in Hashimoto thyroiditis. Deletion of the inhibitor of differentiation 2 (Id2) gene, essential for generation of CD3 -CD4 + lymphoid tissue-inducer (LTi) cells and development of secondary lymphoid organs, did not affect formation of tertiary lymphoid structures. Rather, mature CD3 +CD4 + T cells were critical for the development of tertiary lymphoid structures. The initial stages of this process involved interaction of CD3 +CD4 + T cells with DCs, the appearance of peripheral-node addressin-positive (PNAd +) vessels, and production of chemokines that recruit lymphocytes and DCs. These findings indicate that the formation of tertiary lymphoid structures does not require Id2-dependent conventional LTis but depends on a program initiated by mature CD3 +CD4 + T cells.

Original languageEnglish (US)
Pages (from-to)2622-2632
Number of pages11
JournalJournal of Clinical Investigation
Volume116
Issue number10
DOIs
StatePublished - Oct 2 2006

Fingerprint

Dendritic Cells
Thyroid Gland
T-Lymphocytes
CC Chemokines
Hashimoto Disease
Essential Genes
Lymphoid Tissue
Helper-Inducer T-Lymphocytes
Chemokines
Lymphocytes
Ligands
Tertiary Lymphoid Structures
Ectopic Gene Expression

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Interaction of mature CD3+CD4+ T cells with dendritic cells triggers the development of tertiary lymphoid structures in the thyroid. / Marinkovic, Tatjana; Garin, Alexandre; Yokota, Yoshifumi; Fu, Yang Xin; Ruddle, Nancy H.; Furtado, Glaucia C.; Lira, Sergio A.

In: Journal of Clinical Investigation, Vol. 116, No. 10, 02.10.2006, p. 2622-2632.

Research output: Contribution to journalArticle

Marinkovic, Tatjana ; Garin, Alexandre ; Yokota, Yoshifumi ; Fu, Yang Xin ; Ruddle, Nancy H. ; Furtado, Glaucia C. ; Lira, Sergio A. / Interaction of mature CD3+CD4+ T cells with dendritic cells triggers the development of tertiary lymphoid structures in the thyroid. In: Journal of Clinical Investigation. 2006 ; Vol. 116, No. 10. pp. 2622-2632.
@article{4788fa281de747168c8389423342c4b0,
title = "Interaction of mature CD3+CD4+ T cells with dendritic cells triggers the development of tertiary lymphoid structures in the thyroid",
abstract = "Ectopic expression of CC chemokine ligand 21 (CCL21) in the thyroid leads to development of lymphoid structures that resemble those observed in Hashimoto thyroiditis. Deletion of the inhibitor of differentiation 2 (Id2) gene, essential for generation of CD3 -CD4 + lymphoid tissue-inducer (LTi) cells and development of secondary lymphoid organs, did not affect formation of tertiary lymphoid structures. Rather, mature CD3 +CD4 + T cells were critical for the development of tertiary lymphoid structures. The initial stages of this process involved interaction of CD3 +CD4 + T cells with DCs, the appearance of peripheral-node addressin-positive (PNAd +) vessels, and production of chemokines that recruit lymphocytes and DCs. These findings indicate that the formation of tertiary lymphoid structures does not require Id2-dependent conventional LTis but depends on a program initiated by mature CD3 +CD4 + T cells.",
author = "Tatjana Marinkovic and Alexandre Garin and Yoshifumi Yokota and Fu, {Yang Xin} and Ruddle, {Nancy H.} and Furtado, {Glaucia C.} and Lira, {Sergio A.}",
year = "2006",
month = "10",
day = "2",
doi = "10.1172/JCI28993",
language = "English (US)",
volume = "116",
pages = "2622--2632",
journal = "Journal of Clinical Investigation",
issn = "0021-9738",
publisher = "The American Society for Clinical Investigation",
number = "10",

}

TY - JOUR

T1 - Interaction of mature CD3+CD4+ T cells with dendritic cells triggers the development of tertiary lymphoid structures in the thyroid

AU - Marinkovic, Tatjana

AU - Garin, Alexandre

AU - Yokota, Yoshifumi

AU - Fu, Yang Xin

AU - Ruddle, Nancy H.

AU - Furtado, Glaucia C.

AU - Lira, Sergio A.

PY - 2006/10/2

Y1 - 2006/10/2

N2 - Ectopic expression of CC chemokine ligand 21 (CCL21) in the thyroid leads to development of lymphoid structures that resemble those observed in Hashimoto thyroiditis. Deletion of the inhibitor of differentiation 2 (Id2) gene, essential for generation of CD3 -CD4 + lymphoid tissue-inducer (LTi) cells and development of secondary lymphoid organs, did not affect formation of tertiary lymphoid structures. Rather, mature CD3 +CD4 + T cells were critical for the development of tertiary lymphoid structures. The initial stages of this process involved interaction of CD3 +CD4 + T cells with DCs, the appearance of peripheral-node addressin-positive (PNAd +) vessels, and production of chemokines that recruit lymphocytes and DCs. These findings indicate that the formation of tertiary lymphoid structures does not require Id2-dependent conventional LTis but depends on a program initiated by mature CD3 +CD4 + T cells.

AB - Ectopic expression of CC chemokine ligand 21 (CCL21) in the thyroid leads to development of lymphoid structures that resemble those observed in Hashimoto thyroiditis. Deletion of the inhibitor of differentiation 2 (Id2) gene, essential for generation of CD3 -CD4 + lymphoid tissue-inducer (LTi) cells and development of secondary lymphoid organs, did not affect formation of tertiary lymphoid structures. Rather, mature CD3 +CD4 + T cells were critical for the development of tertiary lymphoid structures. The initial stages of this process involved interaction of CD3 +CD4 + T cells with DCs, the appearance of peripheral-node addressin-positive (PNAd +) vessels, and production of chemokines that recruit lymphocytes and DCs. These findings indicate that the formation of tertiary lymphoid structures does not require Id2-dependent conventional LTis but depends on a program initiated by mature CD3 +CD4 + T cells.

UR - http://www.scopus.com/inward/record.url?scp=33749425111&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33749425111&partnerID=8YFLogxK

U2 - 10.1172/JCI28993

DO - 10.1172/JCI28993

M3 - Article

C2 - 16998590

AN - SCOPUS:33749425111

VL - 116

SP - 2622

EP - 2632

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

SN - 0021-9738

IS - 10

ER -