Interactions of prostate cancer cells to human microvascular endothelial cells under shear stress conditions

Hao Xu, Nene Kalu, Pavithra Raghavan, Myoung H. Kim, Kytai Truong Nguyen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The interactions between prostate cancer cells with endothelial cells in the microvessels play an important role in prostate tumor metastasis. However, not many studies have been conducted to investigate the adhesion of prostate cancer cells on vascular endothelium and related mechanisms and modulators. In this study, human microvascular endothelial cells (HMEC) grown on glass slides were exposed to two different circulating prostate cancer cells, PC-3 and PC-3ML (highly metastasis prostate cancer cells) using an in vitro parallel flow system. The gene profiles of HMEC, after exposure to prostate cancer cells, were also investigated using cDNA microarrays. It was found that PC-3ML cells had significantly higher adhesion than PC-3 cells on HMEC monolayer. In addition, PC-3ML cells trigged more gene changes of HMEC than PC-3 cells did. These results suggested that prostate cancer cells might increase their adhesion to vascular endothelial cells by affecting the endothelial cell on the gene expression level.

Original languageEnglish (US)
Title of host publication2007 IEEE Dallas Engineering in Medicine and Biology Workshop, DEMBS
Pages126-129
Number of pages4
DOIs
Publication statusPublished - 2007
Event2007 IEEE Dallas Engineering in Medicine and Biology Workshop, DEMBS - Richardson, TX, United States
Duration: Nov 11 2007Nov 12 2007

Other

Other2007 IEEE Dallas Engineering in Medicine and Biology Workshop, DEMBS
CountryUnited States
CityRichardson, TX
Period11/11/0711/12/07

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Xu, H., Kalu, N., Raghavan, P., Kim, M. H., & Nguyen, K. T. (2007). Interactions of prostate cancer cells to human microvascular endothelial cells under shear stress conditions. In 2007 IEEE Dallas Engineering in Medicine and Biology Workshop, DEMBS (pp. 126-129). [4454190] https://doi.org/10.1109/EMBSW.2007.4454190