Interactions with WNK (With No Lysine) family members regulate oxidative stress response 1 and ion co-transporter activity

Samarpita Sengupta, Szu Wei Tu, Kyle Wedin, Svetlana Earnest, Steve Stippec, Katherine Luby-Phelps, Melanie H. Cobb

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Background: WNK1 binds OSR1 via RFXV motifs and is on intracellular puncta. Results: C-terminal WNK1 segments bind OSR1 and localize to puncta like endogenous WNK1; changes in tonicity decrease WNK1 mobility. Conclusion: Complex interplay of protein-protein interactions, changes in tonicity, and localization control the WNK-OSR1 cascade. Significance: WNK function varies because of family member and splice form expression, protein interactions, and localization.

Original languageEnglish (US)
Pages (from-to)37868-37879
Number of pages12
JournalJournal of Biological Chemistry
Volume287
Issue number45
DOIs
StatePublished - Nov 2 2012

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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