Interactions with WNK (With No Lysine) family members regulate oxidative stress response 1 and ion co-transporter activity

Samarpita Sengupta, Szu Wei Tu, Kyle Wedin, Svetlana Earnest, Steve Stippec, Katherine Luby-Phelps, Melanie H. Cobb

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: WNK1 binds OSR1 via RFXV motifs and is on intracellular puncta. Results: C-terminal WNK1 segments bind OSR1 and localize to puncta like endogenous WNK1; changes in tonicity decrease WNK1 mobility. Conclusion: Complex interplay of protein-protein interactions, changes in tonicity, and localization control the WNK-OSR1 cascade. Significance: WNK function varies because of family member and splice form expression, protein interactions, and localization.

Original languageEnglish (US)
Pages (from-to)37868-37879
Number of pages12
JournalJournal of Biological Chemistry
Volume287
Issue number45
DOIs
StatePublished - Nov 2 2012

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Symporters
Oxidative stress
Lysine
Oxidative Stress
Ions
Proteins

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Interactions with WNK (With No Lysine) family members regulate oxidative stress response 1 and ion co-transporter activity. / Sengupta, Samarpita; Tu, Szu Wei; Wedin, Kyle; Earnest, Svetlana; Stippec, Steve; Luby-Phelps, Katherine; Cobb, Melanie H.

In: Journal of Biological Chemistry, Vol. 287, No. 45, 02.11.2012, p. 37868-37879.

Research output: Contribution to journalArticle

Sengupta, Samarpita ; Tu, Szu Wei ; Wedin, Kyle ; Earnest, Svetlana ; Stippec, Steve ; Luby-Phelps, Katherine ; Cobb, Melanie H. / Interactions with WNK (With No Lysine) family members regulate oxidative stress response 1 and ion co-transporter activity. In: Journal of Biological Chemistry. 2012 ; Vol. 287, No. 45. pp. 37868-37879.
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