TY - JOUR
T1 - Interactive or static reports to guide clinical interpretation of cancer genomics
AU - Gray, Stacy W.
AU - Gagan, Jeffrey
AU - Cerami, Ethan
AU - Cronin, Angel M.
AU - Uno, Hajime
AU - Oliver, Nelly
AU - Lowenstein, Carol
AU - Lederman, Ruth
AU - Revette, Anna
AU - Suarez, Aaron
AU - Lee, Charlotte
AU - Bryan, Jordan
AU - Sholl, Lynette
AU - Van Allen, Eliezer M.
N1 - Publisher Copyright:
© The Author(s) 2018.
PY - 2018
Y1 - 2018
N2 - Objective: Misinterpretation of complex genomic data presents a major challenge in the implementation of precision oncology. We sought to determine whether interactive genomic reports with embedded clinician education and optimized data visualization improved genomic data interpretation. Materials and Methods: We conducted a randomized, vignette-based survey study to determine whether exposure to interactive reports for a somatic gene panel, as compared to static reports, improves physicians' genomic comprehension and report-related satisfaction (overall scores calculated across 3 vignettes, range 0-18 and 1-4, respectively, higher score corresponding with improved endpoints). Results: One hundred and five physicians at a tertiary cancer center participated (29% participation rate): 67% medical, 20% pediatric, 7% radiation, and 7% surgical oncology; 37% female. Prior to viewing the case-based vignettes, 34% of the physicians reported difficulty making treatment recommendations based on the standard static report. After vignette/report exposure, physicians' overall comprehension scores did not differ by report type (mean score: interactive 11.6 vs static 10.5, difference=1.1, 95% CI, -0.3, 2.5, P=.13). However, physicians exposed to the interactive report were more likely to correctly assess sequencing quality (P < .001) and understand when reports needed to be interpreted with caution (eg, low tumor purity; P=.02). Overall satisfaction scores were higher in the interactive group (mean score 2.5 vs 2.1, difference=0.4, 95% CI, 0.2-0.7, P=.001). Discussion and Conclusion: Interactive genomic reports may improve physicians' ability to accurately assess genomic data and increase report-related satisfaction. Additional research in users' genomic needs and efforts to integrate interactive reports into electronic health records may facilitate the implementation of precision oncology.
AB - Objective: Misinterpretation of complex genomic data presents a major challenge in the implementation of precision oncology. We sought to determine whether interactive genomic reports with embedded clinician education and optimized data visualization improved genomic data interpretation. Materials and Methods: We conducted a randomized, vignette-based survey study to determine whether exposure to interactive reports for a somatic gene panel, as compared to static reports, improves physicians' genomic comprehension and report-related satisfaction (overall scores calculated across 3 vignettes, range 0-18 and 1-4, respectively, higher score corresponding with improved endpoints). Results: One hundred and five physicians at a tertiary cancer center participated (29% participation rate): 67% medical, 20% pediatric, 7% radiation, and 7% surgical oncology; 37% female. Prior to viewing the case-based vignettes, 34% of the physicians reported difficulty making treatment recommendations based on the standard static report. After vignette/report exposure, physicians' overall comprehension scores did not differ by report type (mean score: interactive 11.6 vs static 10.5, difference=1.1, 95% CI, -0.3, 2.5, P=.13). However, physicians exposed to the interactive report were more likely to correctly assess sequencing quality (P < .001) and understand when reports needed to be interpreted with caution (eg, low tumor purity; P=.02). Overall satisfaction scores were higher in the interactive group (mean score 2.5 vs 2.1, difference=0.4, 95% CI, 0.2-0.7, P=.001). Discussion and Conclusion: Interactive genomic reports may improve physicians' ability to accurately assess genomic data and increase report-related satisfaction. Additional research in users' genomic needs and efforts to integrate interactive reports into electronic health records may facilitate the implementation of precision oncology.
KW - Cancer
KW - Genetics
KW - Implementation
KW - Pathology
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U2 - 10.1093/JAMIA/OCX150
DO - 10.1093/JAMIA/OCX150
M3 - Article
C2 - 29315417
AN - SCOPUS:85052636854
SN - 1067-5027
VL - 25
SP - 458
EP - 464
JO - Journal of the American Medical Informatics Association
JF - Journal of the American Medical Informatics Association
IS - 5
ER -