Interaural cross correlation of event-related potentials and diffusion tensor imaging in the evaluation of auditory processing disorder: A case study

James Jerger, Jeffrey Martin, Roderick McColl

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

In a previous publication (Jerger et al, 2002), we presented event-related potential (ERP) data on a pair of 10-year-old twin girls (Twins C and E), one of whom (Twin E) showed strong evidence of auditory processing disorder. For the present paper, we analyzed cross-correlation functions of ERP wave-forms generated in response to the presentation of target stimuli to either the right or left ears in a dichotic paradigm. There were four conditions; three involved the processing of real words for either phonemic, semantic, or spectral targets; one involved the processing of a nonword acoustic signal. Marked differences in the cross-correlation functions were observed. In the case of Twin C, cross-correlation functions were uniformly normal across both hemispheres. The functions for Twin E, however, suggest poorly correlated neural activity over the left parietal region during the three word processing conditions, and over the right parietal area in the nonword acoustic condition. Differences between the twins' brains were evaluated using diffusion tensor magnetic resonance imaging (DTI). For Twin E, results showed reduced anisotropy over the length of the midline corpus callosum and adjacent lateral structures, implying reduced myelin integrity. Taken together, these findings suggest that failure to achieve appropriate temporally correlated bihemispheric brain activity in response to auditory stimulation, perhaps as a result of faulty interhemispheric communication via corpus callosum, may be a factor in at least some children with auditory processing disorder.

Original languageEnglish (US)
Pages (from-to)79-87
Number of pages9
JournalJournal of the American Academy of Audiology
Volume15
Issue number1
DOIs
StatePublished - Jan 2004

Fingerprint

Auditory Perceptual Disorders
Diffusion Tensor Imaging
Evoked Potentials
Word Processing
Corpus Callosum
Acoustics
Acoustic Stimulation
Parietal Lobe
Diffusion Magnetic Resonance Imaging
Anisotropy
Brain
Myelin Sheath
Semantics
Ear
Communication

Keywords

  • Auditory processing disorder
  • Cross correlation
  • Dichotic listening
  • Event-related potentials
  • Magnetic resonance imaging
  • Twins

ASJC Scopus subject areas

  • Speech and Hearing
  • Otorhinolaryngology

Cite this

@article{1430a1fddef44f1394a319e663b0c425,
title = "Interaural cross correlation of event-related potentials and diffusion tensor imaging in the evaluation of auditory processing disorder: A case study",
abstract = "In a previous publication (Jerger et al, 2002), we presented event-related potential (ERP) data on a pair of 10-year-old twin girls (Twins C and E), one of whom (Twin E) showed strong evidence of auditory processing disorder. For the present paper, we analyzed cross-correlation functions of ERP wave-forms generated in response to the presentation of target stimuli to either the right or left ears in a dichotic paradigm. There were four conditions; three involved the processing of real words for either phonemic, semantic, or spectral targets; one involved the processing of a nonword acoustic signal. Marked differences in the cross-correlation functions were observed. In the case of Twin C, cross-correlation functions were uniformly normal across both hemispheres. The functions for Twin E, however, suggest poorly correlated neural activity over the left parietal region during the three word processing conditions, and over the right parietal area in the nonword acoustic condition. Differences between the twins' brains were evaluated using diffusion tensor magnetic resonance imaging (DTI). For Twin E, results showed reduced anisotropy over the length of the midline corpus callosum and adjacent lateral structures, implying reduced myelin integrity. Taken together, these findings suggest that failure to achieve appropriate temporally correlated bihemispheric brain activity in response to auditory stimulation, perhaps as a result of faulty interhemispheric communication via corpus callosum, may be a factor in at least some children with auditory processing disorder.",
keywords = "Auditory processing disorder, Cross correlation, Dichotic listening, Event-related potentials, Magnetic resonance imaging, Twins",
author = "James Jerger and Jeffrey Martin and Roderick McColl",
year = "2004",
month = "1",
doi = "10.3766/jaaa.15.1.8",
language = "English (US)",
volume = "15",
pages = "79--87",
journal = "Journal of the American Academy of Audiology",
issn = "1050-0545",
publisher = "American Academy of Audiology",
number = "1",

}

TY - JOUR

T1 - Interaural cross correlation of event-related potentials and diffusion tensor imaging in the evaluation of auditory processing disorder

T2 - A case study

AU - Jerger, James

AU - Martin, Jeffrey

AU - McColl, Roderick

PY - 2004/1

Y1 - 2004/1

N2 - In a previous publication (Jerger et al, 2002), we presented event-related potential (ERP) data on a pair of 10-year-old twin girls (Twins C and E), one of whom (Twin E) showed strong evidence of auditory processing disorder. For the present paper, we analyzed cross-correlation functions of ERP wave-forms generated in response to the presentation of target stimuli to either the right or left ears in a dichotic paradigm. There were four conditions; three involved the processing of real words for either phonemic, semantic, or spectral targets; one involved the processing of a nonword acoustic signal. Marked differences in the cross-correlation functions were observed. In the case of Twin C, cross-correlation functions were uniformly normal across both hemispheres. The functions for Twin E, however, suggest poorly correlated neural activity over the left parietal region during the three word processing conditions, and over the right parietal area in the nonword acoustic condition. Differences between the twins' brains were evaluated using diffusion tensor magnetic resonance imaging (DTI). For Twin E, results showed reduced anisotropy over the length of the midline corpus callosum and adjacent lateral structures, implying reduced myelin integrity. Taken together, these findings suggest that failure to achieve appropriate temporally correlated bihemispheric brain activity in response to auditory stimulation, perhaps as a result of faulty interhemispheric communication via corpus callosum, may be a factor in at least some children with auditory processing disorder.

AB - In a previous publication (Jerger et al, 2002), we presented event-related potential (ERP) data on a pair of 10-year-old twin girls (Twins C and E), one of whom (Twin E) showed strong evidence of auditory processing disorder. For the present paper, we analyzed cross-correlation functions of ERP wave-forms generated in response to the presentation of target stimuli to either the right or left ears in a dichotic paradigm. There were four conditions; three involved the processing of real words for either phonemic, semantic, or spectral targets; one involved the processing of a nonword acoustic signal. Marked differences in the cross-correlation functions were observed. In the case of Twin C, cross-correlation functions were uniformly normal across both hemispheres. The functions for Twin E, however, suggest poorly correlated neural activity over the left parietal region during the three word processing conditions, and over the right parietal area in the nonword acoustic condition. Differences between the twins' brains were evaluated using diffusion tensor magnetic resonance imaging (DTI). For Twin E, results showed reduced anisotropy over the length of the midline corpus callosum and adjacent lateral structures, implying reduced myelin integrity. Taken together, these findings suggest that failure to achieve appropriate temporally correlated bihemispheric brain activity in response to auditory stimulation, perhaps as a result of faulty interhemispheric communication via corpus callosum, may be a factor in at least some children with auditory processing disorder.

KW - Auditory processing disorder

KW - Cross correlation

KW - Dichotic listening

KW - Event-related potentials

KW - Magnetic resonance imaging

KW - Twins

UR - http://www.scopus.com/inward/record.url?scp=2542439892&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2542439892&partnerID=8YFLogxK

U2 - 10.3766/jaaa.15.1.8

DO - 10.3766/jaaa.15.1.8

M3 - Article

C2 - 15030103

AN - SCOPUS:2542439892

VL - 15

SP - 79

EP - 87

JO - Journal of the American Academy of Audiology

JF - Journal of the American Academy of Audiology

SN - 1050-0545

IS - 1

ER -