Intercalation-mediated nucleic acid nanoparticles for siRNA delivery

Kejin Zhou, Petra Kos, Yunfeng Yan, Hu Xiong, Yi Li Min, Karina A. Kinghorn, Jonathan T. Minnig, Jason B. Miller, Daniel J. Siegwart

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Tremendous effort has been made to improve stability and delivery efficacy of small RNA therapeutics. However, nearly all current nano-encapsulation carriers utilize the critical balance between only two interacting parameters: RNA-binding electrostatic interactions and nanoparticle-stabilizing hydrophobic interactions. We report the development of intercalation-meditated nucleic acid (IMNA) nanoparticles, which utilize intercalation as a third interaction to enhance small RNA delivery. This toolbox expansion of interaction parameters may inspire the use of additional forces in nanoparticle drug carriers to increase potency and stability.

Original languageEnglish (US)
Pages (from-to)12155-12158
Number of pages4
JournalChemical Communications
Volume52
Issue number82
DOIs
StatePublished - 2016

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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  • Cite this

    Zhou, K., Kos, P., Yan, Y., Xiong, H., Min, Y. L., Kinghorn, K. A., Minnig, J. T., Miller, J. B., & Siegwart, D. J. (2016). Intercalation-mediated nucleic acid nanoparticles for siRNA delivery. Chemical Communications, 52(82), 12155-12158. https://doi.org/10.1039/c6cc06024b