Intercalation-mediated nucleic acid nanoparticles for siRNA delivery

Kejin Zhou; Petra Kos; Yunfeng Yan; Hu Xiong; Yi Li Min; Karina A. Kinghorn; Jonathan T. Minnig; Jason B. Miller; Daniel J. Siegwart

doi:10.1039/c6cc06024b

Intercalation-mediated nucleic acid nanoparticles for siRNA delivery

Kejin Zhou, Petra Kos, Yunfeng Yan, Hu Xiong, Yi Li Min, Karina A. Kinghorn, Jonathan T. Minnig, Jason B. Miller, Daniel J. Siegwart

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Tremendous effort has been made to improve stability and delivery efficacy of small RNA therapeutics. However, nearly all current nano-encapsulation carriers utilize the critical balance between only two interacting parameters: RNA-binding electrostatic interactions and nanoparticle-stabilizing hydrophobic interactions. We report the development of intercalation-meditated nucleic acid (IMNA) nanoparticles, which utilize intercalation as a third interaction to enhance small RNA delivery. This toolbox expansion of interaction parameters may inspire the use of additional forces in nanoparticle drug carriers to increase potency and stability.

Original language	English (US)
Pages (from-to)	12155-12158
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	82
DOIs	https://doi.org/10.1039/c6cc06024b
State	Published - 2016

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
General Chemistry
Catalysis

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10.1039/c6cc06024b

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title = "Intercalation-mediated nucleic acid nanoparticles for siRNA delivery",

abstract = "Tremendous effort has been made to improve stability and delivery efficacy of small RNA therapeutics. However, nearly all current nano-encapsulation carriers utilize the critical balance between only two interacting parameters: RNA-binding electrostatic interactions and nanoparticle-stabilizing hydrophobic interactions. We report the development of intercalation-meditated nucleic acid (IMNA) nanoparticles, which utilize intercalation as a third interaction to enhance small RNA delivery. This toolbox expansion of interaction parameters may inspire the use of additional forces in nanoparticle drug carriers to increase potency and stability.",

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AU - Zhou, Kejin

AU - Kos, Petra

AU - Yan, Yunfeng

AU - Xiong, Hu

AU - Min, Yi Li

AU - Kinghorn, Karina A.

AU - Minnig, Jonathan T.

AU - Miller, Jason B.

AU - Siegwart, Daniel J.

N1 - Publisher Copyright: © The Royal Society of Chemistry 2016.

PY - 2016

Y1 - 2016

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AB - Tremendous effort has been made to improve stability and delivery efficacy of small RNA therapeutics. However, nearly all current nano-encapsulation carriers utilize the critical balance between only two interacting parameters: RNA-binding electrostatic interactions and nanoparticle-stabilizing hydrophobic interactions. We report the development of intercalation-meditated nucleic acid (IMNA) nanoparticles, which utilize intercalation as a third interaction to enhance small RNA delivery. This toolbox expansion of interaction parameters may inspire the use of additional forces in nanoparticle drug carriers to increase potency and stability.

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Intercalation-mediated nucleic acid nanoparticles for siRNA delivery

Abstract

ASJC Scopus subject areas

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