Intercatheter reproducibility of near-infrared spectroscopy for the in vivo detection of coronary lipid core plaques

Abdul Rahman R Abdel-Karim, Bavana V. Rangan, Subhash Banerjee, Emmanouil S. Brilakis

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objectives: To evaluate the intercatheter reproducibility of catheter-based intracoronary near-infrared spectroscopy (NIRS) for the detection of coronary lipid core plaques (LCPs). Background: The intercatheter in vivo reproducibility of coronary NIRS findings has not been evaluated. Methods: NIRS assessment using an automated pullback catheter was performed in triplicates in 10 patients using two different NIRS catheters to evaluate the reproducibility of the lipid core burden index (LCBI). Results: Mean age was 62 ± 7 years, and all patients were men with high prevalence of hypertension (90%), hyperlipidemia (90%), diabetes (50%), and current smoking (50%). The mean LCBI measured by the first and second catheters was 64 ± 55 and 69 ± 47, respectively (intraclass correlation coefficient, 0.97; 95% confidence interval, 0.90-0.99; and Spearman's ρ, 0.95; P < 0.001 for both). The mean LCBI measured again with the second catheter was 71 ± 63 (intraclass correlation coefficient, 0.96; 95% confidence interval, 0.84-0.99; and Spearman's ρ, 0.95; P < 0.001 for both). The mean number of LCPs detected by the first and second catheters was 1.9 ± 1.2 and 2.0 ± 1.5, respectively (intraclass correlation coefficient, 0.75, P = 0.005 and Spearman's ρ, 0.74, P = 0.01). The mean number of LCPs at reimaging with the second catheter was 2.0 ± 1.76 (intraclass correlation coefficient, 0.96 and Spearman's ρ, 0.98; P < 0.001 for both). Conclusion: NIRS measurements of LCP with two different catheters have high reproducibility. The findings support the use of NIRS to assess the status of LCP in patients over time and to assess LCP changes in response to novel treatments.

Original languageEnglish (US)
Pages (from-to)657-661
Number of pages5
JournalCatheterization and Cardiovascular Interventions
Volume77
Issue number5
DOIs
StatePublished - Apr 1 2011

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Near-Infrared Spectroscopy
Catheters
Lipids
Confidence Intervals
Hyperlipidemias
Smoking
Hypertension

Keywords

  • atherosclerosis
  • coronary imaging
  • near-infrared spectroscopy
  • reproducibility

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Intercatheter reproducibility of near-infrared spectroscopy for the in vivo detection of coronary lipid core plaques. / Abdel-Karim, Abdul Rahman R; Rangan, Bavana V.; Banerjee, Subhash; Brilakis, Emmanouil S.

In: Catheterization and Cardiovascular Interventions, Vol. 77, No. 5, 01.04.2011, p. 657-661.

Research output: Contribution to journalArticle

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abstract = "Objectives: To evaluate the intercatheter reproducibility of catheter-based intracoronary near-infrared spectroscopy (NIRS) for the detection of coronary lipid core plaques (LCPs). Background: The intercatheter in vivo reproducibility of coronary NIRS findings has not been evaluated. Methods: NIRS assessment using an automated pullback catheter was performed in triplicates in 10 patients using two different NIRS catheters to evaluate the reproducibility of the lipid core burden index (LCBI). Results: Mean age was 62 ± 7 years, and all patients were men with high prevalence of hypertension (90{\%}), hyperlipidemia (90{\%}), diabetes (50{\%}), and current smoking (50{\%}). The mean LCBI measured by the first and second catheters was 64 ± 55 and 69 ± 47, respectively (intraclass correlation coefficient, 0.97; 95{\%} confidence interval, 0.90-0.99; and Spearman's ρ, 0.95; P < 0.001 for both). The mean LCBI measured again with the second catheter was 71 ± 63 (intraclass correlation coefficient, 0.96; 95{\%} confidence interval, 0.84-0.99; and Spearman's ρ, 0.95; P < 0.001 for both). The mean number of LCPs detected by the first and second catheters was 1.9 ± 1.2 and 2.0 ± 1.5, respectively (intraclass correlation coefficient, 0.75, P = 0.005 and Spearman's ρ, 0.74, P = 0.01). The mean number of LCPs at reimaging with the second catheter was 2.0 ± 1.76 (intraclass correlation coefficient, 0.96 and Spearman's ρ, 0.98; P < 0.001 for both). Conclusion: NIRS measurements of LCP with two different catheters have high reproducibility. The findings support the use of NIRS to assess the status of LCP in patients over time and to assess LCP changes in response to novel treatments.",
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