Interchromatidal central ridge and transversal symmetry in early metaphasic human chromosome one

Orlando Argüello-Miranda, Giovanni Sáenz-Arce

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The topographic structure of Giemsa-banded (G-banded) early metaphase human chromosomes adsorbed on glass was analyzed by atomic force microscope using amplitude modulation mode (AM-AFM). Longitudinal height measurements for early metaphasic human chromosomes showed a central ridge that was further characterized by transversal height measurements. The heterochromatic regions displayed a high level of transversal symmetry, while the euchromatic ones presented several peaks across the transversal height measurements. We suggest that this central ridge and symmetry patterns point out a transitional arrangement of the early metaphase chromosome and support evidence for interchromatidal interactions prior to disjunction.

Original languageEnglish (US)
Pages (from-to)184-189
Number of pages6
JournalJournal of Molecular Recognition
Volume21
Issue number3
DOIs
StatePublished - May 1 2008
Externally publishedYes

Keywords

  • AFM
  • Chromosome structure
  • G-banding
  • Interchromatidal interactions

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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