Interfaces between mitochondrial dynamics and disease

Research output: Contribution to journalReview article

21 Scopus citations

Abstract

In the cellular context, mitochondria display a number of dynamic behaviors including fusion, division (or fission), directed transport, and targeted destruction (mitophagy). The relevance of these processes to human diseases has been intensively studied over the last several years, and emphasize the importance of mitochondrial dynamics to the central nervous system. Intriguingly, a common theme is that these behaviors do not function in isolation, but influence one another either directly or indirectly. Here, we review the dynamic properties of mitochondria and summarize their relationships to human diseases.

Original languageEnglish (US)
Pages (from-to)190-198
Number of pages9
JournalCell Calcium
Volume60
Issue number3
DOIs
StatePublished - Sep 1 2016

Keywords

  • Mitochondrial dynamics
  • Mitochondrial fission
  • Mitochondrial fusion
  • Mitochondrial transport
  • Mitophagy

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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