Interfacing peptides, identified using phage-display screening, with quantum dots for the design of nanoprobes

Sawitri Mardyani, Anupam Singhal, Wen Jiang, Warren C.W. Chan

Research output: Contribution to journalConference article

Abstract

The interface of targeting molecules that can recognize and identify specific biomolecules with highly luminescent semiconductor nanocrystals or quantum dots can lead to a novel and powerful new class of probes for studying biomolecules in real-time or for imaging and detecting diseases. We describe the rationale design of optical nanoprobes by using fluorescent semiconductor quantum dots with targeting molecules (TMs)-identified using phage display screening. Quantum dots are nanometer-sized particles with unique and tunable optical properties. They offer numerous optical advantages over traditional organic fluorophores in biological analysis and detection (e.g., photostability, continuous absorption profile).

Original languageEnglish (US)
Article number49
Pages (from-to)217-224
Number of pages8
JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume5705
DOIs
StatePublished - Aug 16 2005
Externally publishedYes
EventNanobiophotonics and Biomedical Applications II - San Jose, CA, United States
Duration: Jan 24 2005Jan 27 2005

Keywords

  • Cell labeling
  • Nanoprobes
  • Optical imaging
  • Phage-display screening
  • Quantum dots
  • Targeting molecules

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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