Interfering with the reconsolidation of traumatic memory

Sirolimus as a novel agent for treating veterans with posttraumatic stress disorder

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Development of novel treatment approaches for combat-related posttraumatic stress disorder (PTSD) is critical, given the increasing prevalence of PTSD in veterans returning from war zone deployment. Established preclinical research using protein synthesis inhibitors (such as sirolimus) to interfere with fear memory reconsolidation provides a compelling rationale for investigation in humans. Methods: This double-blind, placebo-controlled translational pilot study examined the effects of pairing reactivation of a trauma memory with a single administration of sirolimus on the frequency and intensity of PTSD symptoms in male combat veterans. Results: Primary analyses found no significant differences between treatment groups on any of the clinical or physiologic outcome measures. In an exploratory analysis of a subsample of post-Vietnam-era veterans who had more recent combat trauma, PTSD symptom scores fell significantly more in these veterans than in controls. Conclusions: The post-Vietnam-era veteran findings suggest that further investigation of this pairing of sirolimus with traumatic memory reactivation may be warranted. Theoretically, interference with the reconsolidation of fear memories could ameliorate military-related psychological trauma symptoms. Future research should focus on veterans of more recent eras whose traumatic memories may be less entrenched and more amenable to pharmacologic modification within this procedure.

Original languageEnglish (US)
Pages (from-to)33-40
Number of pages8
JournalAnnals of Clinical Psychiatry
Volume25
Issue number1
StatePublished - Feb 2013

Fingerprint

Veterans
Sirolimus
Post-Traumatic Stress Disorders
Vietnam
Fear
Protein Synthesis Inhibitors
Wounds and Injuries
Double-Blind Method
Placebos
Outcome Assessment (Health Care)
Therapeutics
Research

Keywords

  • Memory
  • Memory reconsolidation
  • Novel intervention
  • Pharmacotherapy
  • Posttraumatic stress disorder
  • Trauma
  • Veterans

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

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title = "Interfering with the reconsolidation of traumatic memory: Sirolimus as a novel agent for treating veterans with posttraumatic stress disorder",
abstract = "Development of novel treatment approaches for combat-related posttraumatic stress disorder (PTSD) is critical, given the increasing prevalence of PTSD in veterans returning from war zone deployment. Established preclinical research using protein synthesis inhibitors (such as sirolimus) to interfere with fear memory reconsolidation provides a compelling rationale for investigation in humans. Methods: This double-blind, placebo-controlled translational pilot study examined the effects of pairing reactivation of a trauma memory with a single administration of sirolimus on the frequency and intensity of PTSD symptoms in male combat veterans. Results: Primary analyses found no significant differences between treatment groups on any of the clinical or physiologic outcome measures. In an exploratory analysis of a subsample of post-Vietnam-era veterans who had more recent combat trauma, PTSD symptom scores fell significantly more in these veterans than in controls. Conclusions: The post-Vietnam-era veteran findings suggest that further investigation of this pairing of sirolimus with traumatic memory reactivation may be warranted. Theoretically, interference with the reconsolidation of fear memories could ameliorate military-related psychological trauma symptoms. Future research should focus on veterans of more recent eras whose traumatic memories may be less entrenched and more amenable to pharmacologic modification within this procedure.",
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