TY - JOUR
T1 - Interferon Inducers
T2 - Enhancement of Viral Oncogenesis in Mice and Rats
AU - Gazdar, A. F.
AU - Steinberg, A. D.
AU - Spahn, G. F.
AU - Baron, S.
PY - 1972/4
Y1 - 1972/4
N2 - Pretreatment with several interferon inducers enhanced virus-induced sarcomas and leukemias in mice and rats. Enhancement was dependent on multiple factors including the animal strain, age of mice, and time of treatment. The strain-dependent effects of poly I poly C could not be explained by differences in circulating interferon induction, the extent and duration of the hyporesponsive period to interferon induction, or in the induced antiviral state. Also, there was no correlation between the strain-dependent adjuvant properties of poly I poly C on humoral immunity and its effect on MSV tumor induction. Depending on the conditions, interferon inducers are capable of either enhancing or inhibiting viral oncogenesis.
AB - Pretreatment with several interferon inducers enhanced virus-induced sarcomas and leukemias in mice and rats. Enhancement was dependent on multiple factors including the animal strain, age of mice, and time of treatment. The strain-dependent effects of poly I poly C could not be explained by differences in circulating interferon induction, the extent and duration of the hyporesponsive period to interferon induction, or in the induced antiviral state. Also, there was no correlation between the strain-dependent adjuvant properties of poly I poly C on humoral immunity and its effect on MSV tumor induction. Depending on the conditions, interferon inducers are capable of either enhancing or inhibiting viral oncogenesis.
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U2 - 10.3181/00379727-139-36314
DO - 10.3181/00379727-139-36314
M3 - Article
C2 - 5023305
AN - SCOPUS:0015320557
VL - 139
SP - 1132
EP - 1137
JO - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
JF - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
SN - 1535-3702
IS - 4
ER -