Interferon Inducers: Enhancement of Viral Oncogenesis in Mice and Rats

A. F. Gazdar; A. D. Steinberg; G. F. Spahn; S. Baron

doi:10.3181/00379727-139-36314

Interferon Inducers: Enhancement of Viral Oncogenesis in Mice and Rats

A. F. Gazdar, A. D. Steinberg, G. F. Spahn, S. Baron

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19 Scopus citations

Abstract

Pretreatment with several interferon inducers enhanced virus-induced sarcomas and leukemias in mice and rats. Enhancement was dependent on multiple factors including the animal strain, age of mice, and time of treatment. The strain-dependent effects of poly I poly C could not be explained by differences in circulating interferon induction, the extent and duration of the hyporesponsive period to interferon induction, or in the induced antiviral state. Also, there was no correlation between the strain-dependent adjuvant properties of poly I poly C on humoral immunity and its effect on MSV tumor induction. Depending on the conditions, interferon inducers are capable of either enhancing or inhibiting viral oncogenesis.

Original language	English (US)
Pages (from-to)	1132-1137
Number of pages	6
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	139
Issue number	4
DOIs	https://doi.org/10.3181/00379727-139-36314
State	Published - Apr 1972

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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title = "Interferon Inducers: Enhancement of Viral Oncogenesis in Mice and Rats",

abstract = "Pretreatment with several interferon inducers enhanced virus-induced sarcomas and leukemias in mice and rats. Enhancement was dependent on multiple factors including the animal strain, age of mice, and time of treatment. The strain-dependent effects of poly I poly C could not be explained by differences in circulating interferon induction, the extent and duration of the hyporesponsive period to interferon induction, or in the induced antiviral state. Also, there was no correlation between the strain-dependent adjuvant properties of poly I poly C on humoral immunity and its effect on MSV tumor induction. Depending on the conditions, interferon inducers are capable of either enhancing or inhibiting viral oncogenesis.",

author = "Gazdar, {A. F.} and Steinberg, {A. D.} and Spahn, {G. F.} and S. Baron",

note = "Funding Information: This work was supported, in part, by National Cancer Institute Contract No. PH-43-67-697 4 1972 139 4 1132 1137 ",

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T2 - Enhancement of Viral Oncogenesis in Mice and Rats

AU - Gazdar, A. F.

AU - Steinberg, A. D.

AU - Spahn, G. F.

AU - Baron, S.

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AB - Pretreatment with several interferon inducers enhanced virus-induced sarcomas and leukemias in mice and rats. Enhancement was dependent on multiple factors including the animal strain, age of mice, and time of treatment. The strain-dependent effects of poly I poly C could not be explained by differences in circulating interferon induction, the extent and duration of the hyporesponsive period to interferon induction, or in the induced antiviral state. Also, there was no correlation between the strain-dependent adjuvant properties of poly I poly C on humoral immunity and its effect on MSV tumor induction. Depending on the conditions, interferon inducers are capable of either enhancing or inhibiting viral oncogenesis.

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Interferon Inducers: Enhancement of Viral Oncogenesis in Mice and Rats

Abstract

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