Interferon Inducers: Enhancement of Viral Oncogenesis in Mice and Rats

A. F. Gazdar, A. D. Steinberg, G. F. Spahn, S. Baron

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Pretreatment with several interferon inducers enhanced virus-induced sarcomas and leukemias in mice and rats. Enhancement was dependent on multiple factors including the animal strain, age of mice, and time of treatment. The strain-dependent effects of poly I poly C could not be explained by differences in circulating interferon induction, the extent and duration of the hyporesponsive period to interferon induction, or in the induced antiviral state. Also, there was no correlation between the strain-dependent adjuvant properties of poly I poly C on humoral immunity and its effect on MSV tumor induction. Depending on the conditions, interferon inducers are capable of either enhancing or inhibiting viral oncogenesis.

Original languageEnglish (US)
Pages (from-to)1132-1137
Number of pages6
JournalProceedings of the Society for Experimental Biology and Medicine
Volume139
Issue number4
DOIs
StatePublished - Apr 1972

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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