Interferon regulatory factor 3, a pivotal transcription factor for host antiviral responses

Xing Liu, He Xin Shi, Chen Wang

Research output: Contribution to journalReview articlepeer-review

Abstract

The innate immune system is the first line of host defense against viruses. Type I interferons (IFNs), the vital antiviral cytokines, play a critical role in establishing host antiviral state. Induction of type I IFN requires the formation of a multi-protein enhanceosome, including three families of key transcription factors (NF-κB, IRF3/7, and ATF-2/c-Jun). Transcription factor IRF3 (interferon regulatory factor 3) plays a pivotal role and is tightly regulated in this process. Recently, much progress has been made on cellular signal transduction and regulation of IRF3. Relevant advances in IRF3 biology were summarized with respect to its structure, function and regulatory mechanisms.

Original languageEnglish (US)
Pages (from-to)817-825
Number of pages9
JournalProgress in Biochemistry and Biophysics
Volume37
Issue number8
StatePublished - Aug 2010

Keywords

  • Antiviral mechanism
  • Interferon regulatory factor 3
  • Post-translational modification
  • Signal transduction
  • Transcription regulation

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry

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